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FLASH GENE
Symbol SHANK2 contributors: mct/npt - updated : 20-05-2015
HGNC name SH3 and multiple ankyrin repeat domains 2
HGNC id 14295
ANIMAL & CELL MODELS
  • the postnatal expression of the SHANK2-R462X in mice can lead to impaired cognitive functions
  • reduced Nmdar function may contribute to the development of ASD-like phenotypes in Shank2(-/-) mice, and Grm8 modulation of Nmdars offers a potential strategy to treat Autism spectrum disorder (ASD)