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FLASH GENE
Symbol SFTPD contributors: mct - updated : 22-05-2018
HGNC name surfactant, pulmonary-associated protein D
HGNC id 10803
Location 10q22.3      Physical location : 81.697.497 - 81.708.861
Synonym name
  • collectin 7
  • pulmonary surfactant apoprotein
  • surfactant-associated protein, pulmonary 4
    • Synonym symbol(s) PSP-D, SFTP4, SP-D, PSP-D, SFTP4, COLEC7
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1299 - 375 - Kobayashi (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
     respiratory tractlarynx   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a collagen-like region
  • carbohydrate recognition domains (CRD)
  • a neck domain plus CRD (NCRD)
  • a C-type lectin family domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY collectin family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
  • plays important roles in lipopolysaccharide (LPS) recognition
  • plays diverse and important roles in innate immunity and pulmonary homeostasis (Crouch 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with decorin, a SFTPD-binding protein (decorin core protein binds the collagen-like region of the SFTPD)
  • binds the extracellular domains of TLR2 and TLR4 through its CRD by a mechanism different from its binding to PI and LPS
  • putative binding motif for OSCAR within the SFTPD collagenous domain, and interaction is a potential therapeutic target in chronic inflammatory diseases of the lung as well as other diseases involving tissue accumulation of SFTPD, infiltration of inflammatory monocytes
    • cell & other
    REGULATION
    inhibited by MPO (Myeloperoxidase-dependent inactivation of surfactant protein D) (Crouch 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sftpd mutant lacking N-terminal cysteine residues and truncation mutants lacking the N-terminal domains were resistant to the oxidant-induced alterations in disulfide bonding (Crouch 2010)