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FLASH GENE
Symbol SFTPD contributors: mct - updated : 22-05-2018
HGNC name surfactant, pulmonary-associated protein D
HGNC id 10803
Location 10q22.3      Physical location : 81.697.497 - 81.708.861
Synonym name
  • collectin 7
  • pulmonary surfactant apoprotein
  • surfactant-associated protein, pulmonary 4
  • Synonym symbol(s) PSP-D, SFTP4, SP-D, PSP-D, SFTP4, COLEC7
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC387691 10 LOC387691 RAI17 10q23.2 retinoic acid induced 17 PPIF 10q22.3 peptidylprolyl isomerase F (cyclophilin F) FLJ90798 10q23.1 hypothetical protein FLJ90798 LOC338586 10q23.1 similar to XRnf12C LOC143244 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A LOC389981 10 similar to mannose-binding protein A LOC389982 10 similar to mKIAA1553 protein LOC387692 10 similar to KIAA2020 protein EIF5AP1 10q23.3 eukaryotic translation initiation factor 5A pseudogene 1 LOC389983 10 similar to Gene with similarity to rat kidney-specific (KS) gene SFTPA2 10q22-q23 surfactant, pulmonary-associated protein A2 SFTPA1 10q22.3 surfactant, pulmonary-associated protein A1 LOC389984 10 similar to KIAA1553 protein LOC389985 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389986 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC340736 10q23.1 similar to Cathepsin L preproprotein LOC283004 10q23.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) LOC387693 10 similar to BMS1-like, ribosome assembly protein; ribosome biogenesis protein BMS1 homolog; cDNA sequence BC030906; EST AA408648 SFTPD 10q22.3 surfactant, pulmonary-associated protein D LOC389987 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389988 10 similar to nuclear DNA-binding protein; small unique nuclear receptor corepressor; C1D DNA-binding protein LOC389989 10 hypothetical gene supported by BC016284; NM_173177 FLJ13263 10q23.1 hypothetical protein FLJ13263 PLAC9 10q23.2 placenta-specific 9 ANXA11 10q22.3 annexin A11 LOC143243 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A MAT1A 10q22 methionine adenosyltransferase I, alpha LOC143241 10q23.1 hypothetical protein BC019250 MGC16186 10q23.1 hypothetical protein MGC16186 MGC4248 10q23.1 hypothetical protein MGC4248 DC-TM4F2 10q23.1 tetraspanin similar to TM4SF9 LOC387694 10 similar to hypothetical protein D030001E08 LOC389990 10 similar to Replication protein A 32 kDa subunit (RP-A) (RF-A) (Replication factor-A protein 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1299 - 375 - Kobayashi (2008)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
     respiratory tractlarynx   
    Visualeyeretina   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a collagen-like region
  • carbohydrate recognition domains (CRD)
  • a neck domain plus CRD (NCRD)
  • a C-type lectin family domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY collectin family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
  • plays important roles in lipopolysaccharide (LPS) recognition
  • plays diverse and important roles in innate immunity and pulmonary homeostasis (Crouch 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with decorin, a SFTPD-binding protein (decorin core protein binds the collagen-like region of the SFTPD)
  • binds the extracellular domains of TLR2 and TLR4 through its CRD by a mechanism different from its binding to PI and LPS
  • putative binding motif for OSCAR within the SFTPD collagenous domain, and interaction is a potential therapeutic target in chronic inflammatory diseases of the lung as well as other diseases involving tissue accumulation of SFTPD, infiltration of inflammatory monocytes
  • cell & other
    REGULATION
    inhibited by MPO (Myeloperoxidase-dependent inactivation of surfactant protein D) (Crouch 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sftpd mutant lacking N-terminal cysteine residues and truncation mutants lacking the N-terminal domains were resistant to the oxidant-induced alterations in disulfide bonding (Crouch 2010)