Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SFTPD contributors: mct - updated : 22-05-2018
HGNC name surfactant, pulmonary-associated protein D
HGNC id 10803
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
 respiratory tractlarynx   
Visualeyeretina   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a collagen-like region
  • carbohydrate recognition domains (CRD)
  • a neck domain plus CRD (NCRD)
  • a C-type lectin family domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY collectin family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • playing an important role in innate immunity by binding to specific carbohydrate structures found at the surface of pathogenic microorganisms
  • plays important roles in lipopolysaccharide (LPS) recognition
  • plays diverse and important roles in innate immunity and pulmonary homeostasis (Crouch 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with decorin, a SFTPD-binding protein (decorin core protein binds the collagen-like region of the SFTPD)
  • binds the extracellular domains of TLR2 and TLR4 through its CRD by a mechanism different from its binding to PI and LPS
  • putative binding motif for OSCAR within the SFTPD collagenous domain, and interaction is a potential therapeutic target in chronic inflammatory diseases of the lung as well as other diseases involving tissue accumulation of SFTPD, infiltration of inflammatory monocytes
  • cell & other
    REGULATION
    inhibited by MPO (Myeloperoxidase-dependent inactivation of surfactant protein D) (Crouch 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Sftpd mutant lacking N-terminal cysteine residues and truncation mutants lacking the N-terminal domains were resistant to the oxidant-induced alterations in disulfide bonding (Crouch 2010)