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FLASH GENE
Symbol SFN contributors: mct/npt/pgu - updated : 26-06-2012
HGNC name stratifin
HGNC id 10773
Location 1p36.11      Physical location : 27.189.632 - 27.190.947
Synonym name
  • 14.3.3 protein sigma
  • epithelial cell marker protein 1
  • Synonym symbol(s) HME1, 14-3-3 sigma, YWHAS
    DNA
    TYPE functioning gene
    STRUCTURE 1.31 kb     1 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EXTL1 1p36.1 exostoses (multiple)-like 1 SLC30A2 1p35.3 solute carrier family 30 (zinc transporter), member 2 RNF28 1p34-p33 ring finger protein 28 LOC149420 1p35.3 casein kinase FLJ14050 1p35.3 hypothetical protein FLJ14050 ZT86 1p35.3 zinc finger protein CNK1 1p35.3 zinc finger protein CATSPER4 1p35.3 cation channel, sperm associated 4 LOC391021 1 similar to secreted acid phosphatase 2 (SAP2) DKFZP434L0117 1p35.3 hypothetical protein DKFZp434L0117 MRPS6P1 1p35 mitochondrial ribosomal protein S6 pseudogene 1 SH3BGRL3 1p35-p34.3 SH3 domain binding glutamic acid-rich protein like 3 SOC 1p35.3 SH3 domain binding glutamic acid-rich protein like 3 CDW52 1p36 CDW52 antigen (CAMPATH-1 antigen) AIM1L 1p35.3 absent in melanoma 1-like MGC33414 1p35.3 hypothetical protein MGC33414 LIN28 1p35.3 lin-28 homolog (C. elegans) DHDDS 1p35.3 dehydrodolichyl diphosphate synthase HMGN2 1p36.1 high-mobility group nucleosomal binding domain 2 RPS6KA1 1p36-p35 ribosomal protein S6 kinase, 90kDa, polypeptide 1 SMARCF1 1p36.1-p35 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 FLJ20477 1p35.3 hypothetical protein FLJ20477 ZDHHC18 1p35.3 zinc finger, DHHC domain containing 18 SFN 1p35.3 stratifin FLJ10349 1p35.3 hypothetical protein FLJ10349 FLJ12455 1p35.3-p35.1 hypothetical protein FLJ12455 NR0B2 1p36.1 nuclear receptor subfamily 0, group B, member 2 NUDC 1p35-p34 nuclear distribution gene C homolog (A. nidulans) FLJ34633 1p35.3 hypothetical protein FLJ34633 LOC391022 1 similar to DC2 protein LOC388610 1 LOC388610 MGC16491 1p35.3 hypothetical protein MGC16491 SLC9A1 1p35 solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) LOC391023 1 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC284609 1p35.3 similar to hypothetical protein FLJ20420 LOC148356 1p35.3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 WDTC1 1p35.3 WD and tetratricopeptide repeats 1 DKFZP564D0478 1p35.3 hypothetical protein DKFZp564D0478 JFC1 1p35.3 hypothetical protein DKFZp564D0478 MAP3K6 1p35.2 mitogen-activated protein kinase kinase kinase 6 FCN3 1p36-p32 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) LOC388611 1 similar to EAPG6122 GPR3 1p35.1-p34.3 G protein-coupled receptor 3 WASF2 1p36.11-p34.3 WAS protein family, member 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1336 27.8 248 - 2006 16902409
  • 143S (SFNA)
  • - splicing - 26.8 237 - 2006 16902409
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     mouth   highly
    Endocrinepancreas   highly
    Nervousnervecranial nerve  highly
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin   highly
    Visualeyeanterior segmentcornea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum basale 
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Mkrn3
    Homologene
    FAMILY
  • 14.3.3 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • may be involved in negative regulation of protein kinase activity, cell proliferation, signal transduction, regulation of cell cycle
  • implicated in G2/M cell cycle arrest by Tp53 (Kuroda 2007)
  • acts as a tumor suppressor and is often inactivated during tumor development
  • having function linked to epidermal stratification and differentiation in the skin (Xin 2010)
  • critical for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity (Xin 2010)
  • important G2M cell cycle checkpoint regulator and its expression is induced by DNA damage stress through a TP53-dependent pathway (Xin 2010)
  • regulates corneal epithelial cell proliferation and differentiation by maintaining Notch activity (Xin 2010)
  • plays a critical role in retaining epithelial polarity, through its interaction with PARD3 (Ling 2010)
  • plays a critical role in retaining epithelial polarity
  • regulates cytokinesis and cell cycle arrest induced by DNA damage
  • maintains FOXO1 at a consistent level critical for normal B-cell antigen receptor signaling and B-cell survival
  • its levels are critical for maintaining TP53 activity in response to DNA damage and regulating signal mediators such as AKT1
  • TP63 and SFN play opposing roles in the development of skin tumors and the accumulation of TP63 is essential for Ras/SFN mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
  • intracellular, phosphoserine binding protein, playing a regulatory role in epidermal epithelial differentiation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IRF6 for the keratinocyte proliferation-differentiation switch
  • target of CA11 (for degradation, leading to MDM2 stabilization)
  • binds to p37 AUF1, retains it in the cytoplasm probably by masking its NLS, and enhances rapid turnover of ARE (AU-rich destabilizing element)-mRNAs
  • targets RFWD2 for nuclear export, thereby preventing RFWD2-mediated TP53 nuclear export
  • LRFN4 complexed with SFN and NCK1 to mediate elongation in monocytic cells via RAC-1-mediated actin cytoskeleton reorganization
  • cell & other
    REGULATION
    induced by TP53 in response to DNA damage
    Other COPS6 associates with RFWD2 and is involved in SFN ubiquitin-mediated degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in mammary carcinoma by hypermethylation and invulval squamous neoplasia
    tumoral     --low  
    in prostate cancer
    tumoral     --low  
    involved in the uncontrolled cell cycle in intrahepatic cholangiocarcinoma and is a significant indicator of poor prognosis for patients with intrahepatic cholangiocarcinoma
    tumoral     --over  
    in gastric cancer, significantly correlated with clinical stage and tumor invasion
    tumoral     --over  
    hypomethylation of the promoter leads to increased expression in non-small cell lung cancer
    tumoral        
    epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    therapeutic molecular target for gastric cancer
    ANIMAL & CELL MODELS