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FLASH GENE

Symbol

SFN

contributors: mct/npt/pgu - updated : 26-06-2012

HGNC name	stratifin
HGNC id	10773

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.11      Physical location : 27.189.632 - 27.190.947
Synonym name	14.3.3 protein sigma
	epithelial cell marker protein 1
Synonym symbol(s)	HME1, 14-3-3 sigma, YWHAS

DNA

TYPE	functioning gene
STRUCTURE	1.31 kb     1 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006142 1 - 1336 NP_006133 27.8 248 - 2006 16902409 143S (SFNA) ORN (SFNS) - splicing - 26.8 237 - 2006 16902409

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   mouth       highly Endocrine pancreas       highly Nervous nerve cranial nerve     highly Reproductive male system prostate     highly Skin/Tegument skin       highly Visual eye anterior segment cornea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum basale   Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Mkrn3

Homologene

FAMILY

14.3.3 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	may be involved in negative regulation of protein kinase activity, cell proliferation, signal transduction, regulation of cell cycle
	implicated in G2/M cell cycle arrest by Tp53 (Kuroda 2007)
	acts as a tumor suppressor and is often inactivated during tumor development
	having function linked to epidermal stratification and differentiation in the skin (Xin 2010)
	critical for regulating corneal epithelial proliferation and differentiation by regulating Notch signaling activity (Xin 2010)
	important G2M cell cycle checkpoint regulator and its expression is induced by DNA damage stress through a TP53-dependent pathway (Xin 2010)
	regulates corneal epithelial cell proliferation and differentiation by maintaining Notch activity (Xin 2010)
	plays a critical role in retaining epithelial polarity, through its interaction with PARD3 (Ling 2010)
	plays a critical role in retaining epithelial polarity
	regulates cytokinesis and cell cycle arrest induced by DNA damage
	maintains FOXO1 at a consistent level critical for normal B-cell antigen receptor signaling and B-cell survival
	its levels are critical for maintaining TP53 activity in response to DNA damage and regulating signal mediators such as AKT1
	TP63 and SFN play opposing roles in the development of skin tumors and the accumulation of TP63 is essential for Ras/SFN mutation-induced papilloma formation and squamous cell carcinoma carcinogenesis
	intracellular, phosphoserine binding protein, playing a regulatory role in epidermal epithelial differentiation

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with IRF6 for the keratinocyte proliferation-differentiation switch
	target of CA11 (for degradation, leading to MDM2 stabilization)
	binds to p37 AUF1, retains it in the cytoplasm probably by masking its NLS, and enhances rapid turnover of ARE (AU-rich destabilizing element)-mRNAs
	targets RFWD2 for nuclear export, thereby preventing RFWD2-mediated TP53 nuclear export
	LRFN4 complexed with SFN and NCK1 to mediate elongation in monocytic cells via RAC-1-mediated actin cytoskeleton reorganization

cell & other

REGULATION

induced by

TP53 in response to DNA damage

Other

COPS6 associates with RFWD2 and is involved in SFN ubiquitin-mediated degradation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in mammary carcinoma by hypermethylation and invulval squamous neoplasia tumoral     --low   in prostate cancer tumoral     --low   involved in the uncontrolled cell cycle in intrahepatic cholangiocarcinoma and is a significant indicator of poor prognosis for patients with intrahepatic cholangiocarcinoma tumoral     --over   in gastric cancer, significantly correlated with clinical stage and tumor invasion tumoral     --over   hypomethylation of the promoter leads to increased expression in non-small cell lung cancer tumoral         epigenetic silencing of 14-3-3sigma might contribute to tumor progression in malignant melanoma via loss of cell cycle control, impaired cellular senescence program

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach therapeutic molecular target for gastric cancer

ANIMAL & CELL MODELS