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FLASH GENE
Symbol SFMBT1 contributors: mct - updated : 21-10-2014
HGNC name Scm-like with four mbt domains 1
HGNC id 20255
Location 3p21.31      Physical location : 52.937.583 - 53.080.089
Synonym name
  • Scm-related gene containing four mbt domains
  • renal ubiquitous protein 1
    • Synonym symbol(s) RU1, SFMBT
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 141.00 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratorylung   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four MBT repeats, sufficient and necessary for nuclear matrix attachment, transcriptional repression and histone binding, that may potentially bind methyl lysines
  • a C2-C2 zinc finger
  • a SAM (sterile alpha motif) domain
    • HOMOLOGY
    interspecies homolog to Drosophila sex comb on midleg (scm)
    homolog to murine Sfmbt1
    intraspecies homolog to SCML2
    Homologene
    FAMILY malignant brain tumor (MBT) domain-containing protein family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized to the nucleus where it strongly associates with chromatin by directly and selectively binding the N-terminal tail of histone H3
    basic FUNCTION
  • may be implicated in the regulation of transcription
  • may be an important regulator of transcriptional programs during developmental and differentiation processes
  • essential role of SFMBT1 in regulating MYOD1-mediated transcriptional silencing that is required for the maintenance of undifferentiated states of myogenic progenitor cells
  • critical role of SFMBT1 in epigenetic regulation, EMT, and cancer
  • is essential for SNAI1-mediated transcriptional repression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a novel, integral component of the KDM1A complex
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • strongly interacts with the nuclear matrix and also selectively binds histones H3 and H4
  • regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with KDM1A and RCOR1
  • SFMBT1 associates with the KDM1A complex and is essential for its chromatin association, histone demethylation, and induction of EMT
  • is essential for SNAI1-dependent recruitment of KDM1A to chromatin, demethylation of H3K4me2, transcriptional repression of epithelial markers, and induction of EMT by TGFB1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS