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Symbol SFMBT1 contributors: mct - updated : 21-10-2014
HGNC name Scm-like with four mbt domains 1
HGNC id 20255
Location 3p21.31      Physical location : 52.937.583 - 53.080.089
Synonym name
  • Scm-related gene containing four mbt domains
  • renal ubiquitous protein 1
  • Synonym symbol(s) RU1, SFMBT
    TYPE anonymous DNA segment
    STRUCTURE 141.00 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    PCBP4 3p21 poly(rC) binding protein 4 MGC15429 3p21.31 hypothetical protein MGC15429 DKFZP564O243 3p21.1 DKFZP564O243 protein ACY1 3p21.1 aminoacylase 1 RPL29 3q29 ribosomal protein L29 DUSP7 3p21.1 dual specificity phosphatase 7 DKFZP434C245 3p21.31 DKFZP434C245 protein LOC391538 3 similar to fructose-1,6-bisphosphate aldolase A ALAS1 3p21.1 aminolevulinate, delta-, synthase 1 TLR9 3p21.3 toll-like receptor 9 PTK9L 3p21.1 PTK9L protein tyrosine kinase 9-like (A6-related protein) FLJ32332 3p21.31 likely ortholog of mouse protein phosphatase 2C eta PRO2730 3p21.31 hypothetical protein PRO2730 GLYCTK 3p21.31 CG9886-like PPP2R5CP 3p21.3 protein phosphatase 2, regulatory subunit B (B56), gamma isoform pseudogene BAP1 3p21.31-p21.2 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) PHF7 3p21.31 PHD finger protein 7 LOC56920 3p21.31 semaphorin sem2 TNNC1 3p21.3-p14.3 troponin C, slow NISCH 3p21.1 nischarin STAB1 3p21.31 stabilin 1 FLJ12442 3p21.31 hypothetical protein FLJ12442 PB1 3p21 hypothetical protein FLJ12442 NS 3p21.31 nucleostemin AD-017 3p21.31 glycosyltransferase AD-017 SPC12 3p21.31 signal peptidase 12kDa NEK4 3p21.1 NIMA (never in mitosis gene a)-related kinase 4 ITIH1 3p21.2-p21.1 inter-alpha (globulin) inhibitor, H1 polypeptide ITIH3 3p21.2-p21.1 pre-alpha (globulin) inhibitor, H3 polypeptide ITIH4 3p21.2-p21.1 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) LOC389125 3 similar to hypothetical protein MGC52022 3p21.31 Similar to RIKEN cDNA 1810038N08 gene SFMBT1 3p21.31 Scm-like with four mbt domains 1 LOC285398 3p21.31 hypothetical protein LOC285398 RFT1 3p21.31 putative endoplasmic reticulum multispan transmembrane protein PRKCD 3p21.31 protein kinase C, delta TKT 3p14.3 transketolase (Wernicke-Korsakoff syndrome) HSA275986 3p21.31 transcription factor SMIF LOC391539 3 similar to 40S ribosomal protein S25 CACNA1D 3p14.3 calcium channel, voltage-dependent, L type, alpha 1D subunit
    TRANSCRIPTS type messenger
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Reproductivefemale systembreastmammary gland highly
     male systemtestis  highly
    Respiratorylung   lowly
    cell lineage
    cell lines
    at STAGE
  • four MBT repeats, sufficient and necessary for nuclear matrix attachment, transcriptional repression and histone binding, that may potentially bind methyl lysines
  • a C2-C2 zinc finger
  • a SAM (sterile alpha motif) domain
    interspecies homolog to Drosophila sex comb on midleg (scm)
    homolog to murine Sfmbt1
    intraspecies homolog to SCML2
    FAMILY malignant brain tumor (MBT) domain-containing protein family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    text localized to the nucleus where it strongly associates with chromatin by directly and selectively binding the N-terminal tail of histone H3
    basic FUNCTION
  • may be implicated in the regulation of transcription
  • may be an important regulator of transcriptional programs during developmental and differentiation processes
  • essential role of SFMBT1 in regulating MYOD1-mediated transcriptional silencing that is required for the maintenance of undifferentiated states of myogenic progenitor cells
  • critical role of SFMBT1 in epigenetic regulation, EMT, and cancer
  • is essential for SNAI1-mediated transcriptional repression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    a component
  • is a novel, integral component of the KDM1A complex
    DNA binding
    small molecule metal binding,
    zinc Zn2+
  • strongly interacts with the nuclear matrix and also selectively binds histones H3 and H4
  • regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with KDM1A and RCOR1
  • SFMBT1 associates with the KDM1A complex and is essential for its chromatin association, histone demethylation, and induction of EMT
  • is essential for SNAI1-dependent recruitment of KDM1A to chromatin, demethylation of H3K4me2, transcriptional repression of epithelial markers, and induction of EMT by TGFB1
  • cell & other