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FLASH GENE
Symbol SFMBT1 contributors: mct - updated : 21-10-2014
HGNC name Scm-like with four mbt domains 1
HGNC id 20255
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four MBT repeats, sufficient and necessary for nuclear matrix attachment, transcriptional repression and histone binding, that may potentially bind methyl lysines
  • a C2-C2 zinc finger
  • a SAM (sterile alpha motif) domain
    • HOMOLOGY
    interspecies homolog to Drosophila sex comb on midleg (scm)
    homolog to murine Sfmbt1
    intraspecies homolog to SCML2
    Homologene
    FAMILY malignant brain tumor (MBT) domain-containing protein family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text localized to the nucleus where it strongly associates with chromatin by directly and selectively binding the N-terminal tail of histone H3
    basic FUNCTION
  • may be implicated in the regulation of transcription
  • may be an important regulator of transcriptional programs during developmental and differentiation processes
  • essential role of SFMBT1 in regulating MYOD1-mediated transcriptional silencing that is required for the maintenance of undifferentiated states of myogenic progenitor cells
  • critical role of SFMBT1 in epigenetic regulation, EMT, and cancer
  • is essential for SNAI1-mediated transcriptional repression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a novel, integral component of the KDM1A complex
    • INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • strongly interacts with the nuclear matrix and also selectively binds histones H3 and H4
  • regulates transcription in somatic cells and during spermatogenesis through the formation of a stable complex with KDM1A and RCOR1
  • SFMBT1 associates with the KDM1A complex and is essential for its chromatin association, histone demethylation, and induction of EMT
  • is essential for SNAI1-dependent recruitment of KDM1A to chromatin, demethylation of H3K4me2, transcriptional repression of epithelial markers, and induction of EMT by TGFB1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS