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FLASH GENE

Symbol

SERPINF2

contributors: npt/mct - updated : 05-05-2010

HGNC name	serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
HGNC id	9075

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	PLI plasmin inhibitor deficiency
Location	17p13.3      Physical location : 1.646.129 - 1.658.559
Synonym name	alpha-2-plasmin inhibitor
	pigment epithelium derived factor), member 2
Synonym symbol(s)	AAP, API, A2AP, ALPHA-2-PI

DNA

TYPE	functioning gene
STRUCTURE	12.43 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001165921 - - 2126 NP_001159393 - 427 - Bangert (1993) NM_001165920 - - 2296 NP_001159392 - 491 - Bangert (1993) NM_000934 10 - 2284 NP_000925 - 491 - Bangert (1993)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Urinary kidney

cell lineage
cell lines
fluid/secretion	plasma

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

four Cys residues organized into two disulphide bridges

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

serpin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus

basic FUNCTION

serpin involved in the regulation of blood coagulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PLI

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	downregulation of the plasminogen activator/ plasmin system by SERPINF2 might be a potent therapeutic approach to prevent the progression of oral squamous cell carcinoma (Hayashido 2007)

ANIMAL & CELL MODELS