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FLASH GENE
Symbol SERPINF2 contributors: npt/mct - updated : 05-05-2010
HGNC name serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
HGNC id 9075
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Cys residues organized into two disulphide bridges
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • serpin family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • serpin involved in the regulation of blood coagulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PLI
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target downregulation of the plasminogen activator/ plasmin system by SERPINF2 might be a potent therapeutic approach to prevent the progression of oral squamous cell carcinoma (Hayashido 2007)
    ANIMAL & CELL MODELS