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FLASH GENE
Symbol SEMA6D contributors: mct - updated : 25/10/2008
HGNC name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
HGNC id 16770
Location 15q21.1      Physical location : 48.010.685 - 48.066.419
Synonym symbol(s) FLJ11598, KIAA1479
DNA
TYPE functioning gene
STRUCTURE 55.73 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 splicing 5923 - 1011 - Qu (2002)
missing an internal region compared to isoform 4 and contains an internal segment unique to this isoform
17 splicing 5884 - 998 - Qu (2002)
18 splicing 5941 - 1017 - Qu (2002)
19 splicing 6109 - 1073 - Qu (2002)
18 splicing 5919 - 597 - Qu (2002)
missing an internal segment and has a unique C-terminus relative to isoform 4.
- splicing 2290 - 476 - Qu
lacking a PSI domain and a predicted transmembrane domain, putative secreted protein.
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Hearing/Equilibriumear   highly
Nervousbrain   highly
 braindiencephalon   
 brainhindbraincerebellum  
 spinal cord    
Olfactory (smell)olfactory bulb    
Urinarykidney   highly
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text
  • placenta
  • fetal eyes
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a semaphorin (SEMA) domain and a PSI domain
    HOMOLOGY
    Homologene
    FAMILY semaphorin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be playing a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation
  • playing a role as a regulator of the late phase of primary immune responses
  • regulates T cell activation during the late phases of an immune response
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS