basic FUNCTION
| repellent of the nerve growth cone guidance |
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inducing the collapse and paralysis of neuronal growth cones |
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implicated in regulation of sensory innervation of the cornea |
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essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury ( |
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can function as potent anti-tumorigenic agents (but is required expression of appropriate semaphorin receptors by tumor cells) |
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could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism |
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one of the major inhibitors of axonal regeneration, and of other regenerative responses after spinal cord injury |
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neural chemorepellent, involved in cardiac sympathetic innervation patterning, important for the maintenance of arrhythmia-free hearts and playing a critical role for heart rate control |
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playing a crucial role for the cardiac sympathetic patterning, not only during embryonic development but also after birth |
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may function as a chemoattractive guidance signal for the radial migration of newborn cortical neurons toward upper layers |
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may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development |
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enhanced axon growth |
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plays a role in induction of apoptosis in monocyte-derived macrophages that are resistant to Fas-induced apoptosis, and its function can be modulated in inflammatory conditions |
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playing a role as an antiangiogenic factor in meningiomas with its decrease being associated with the development of recurrences |
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PLXNA4 and SEMA3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm |
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induces CACNA1E channel-dependent conversion of axons to dendrites) |
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SEMA3A-mediated signaling and axonal repulsion require VAMP2-dependent vesicular traffic |
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exerts an osteoprotective effect by both suppressing osteoclastic bone resorption and increasing osteoblastic bone formation |
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functions as a potent osteoprotective factor by synchronously inhibiting bone resorption and promoting bone formation |
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inhibits osteoclast differentiation and promotes osteoblastic bone formation, and is thus a potent osteoprotective factor produced by osteoblastic cells |
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secreted factor that navigates axons and dendrites of developing neurons, facilitates axonal transport |
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induces facilitation of axonal transport via local calcium signaling in growth cone |
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requires neuronal activity to promote dendritic complexity, presumably because silencing neurons leads to a proteasome-dependent reduction of PLXNA1 in dendrites |
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role of the PLXNA2 receptor in SEMA3A and SEMA3B signal transduction |
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SEMA3A, -3C, and -3F, likely with coreceptors NRP1, NRP2, and plexin-A1 and/or -A3, promote migration and possibly other activities of human DCs during innate and adaptive immune responses |