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FLASH GENE
Symbol SEMA3A contributors: mct/shn/pgu - updated : 15-10-2017
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
HGNC id 10723
ANIMAL & CELL MODELS
Sema3a-/- mice lacked a cardiac sympathetic innervation gradient and exhibited stellate ganglia malformation, leading to a marked sinus bradycardia due to sympathetic dysfunction (
  • mice mutant in the semaIII gene show in the cerebral cortex paucity of neuropil and abnormally oriented neuronal processes, especially of the large pyramidal neurons and certain embryonic bones and cartilaginous structures develop abnormally, with vertebral fusions and partial rib duplications (