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FLASH GENE
Symbol SEC23B contributors: mct/npt - updated : 04-12-2015
HGNC name Sec23 homolog B (S. cerevisiae)
HGNC id 10702
Corresponding disease
CDAN2 congenital dyserythropoietic anemia, type II
CWS7 Cowden syndrome 7
Location 20p11.23      Physical location : 18.488.187 - 18.542.058
Synonym name
  • transport protein Sec23 isoform A
  • transport protein Sec23 isoform B
  • SEC23-like protein B
  • Sec23 (S. cerevisiae) homolog B
  • Synonym symbol(s) CDA-II, CDAII, CDAN2, HEMPAS
    DNA
    TYPE functioning gene
    STRUCTURE 53.86 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PCSK2 20p11.2 proprotein convertase subtilisin/kexin type 2 BFSP1 20p11.23 beaded filament structural protein 1, filensin RPS27AP2 20p11.2 ribosomal protein S27a pseudogene 2 DSTN 20p11.23 destrin (actin depolymerizing factor) RRBP1 20p12-p11.2 ribosome binding protein 1 homolog 180kDa (dog) C20orf179 20 chromosome 20 open reading frame 179 SNX5 20pter-q11.23 sorting nexin 5 C20orf72 20p11.23 chromosome 20 open reading frame 72 PTMAP3 20p11.23 prothymosin, alpha pseudogene 3 (gene sequence 34) ZNF339 20pter-q11.23 zinc finger protein 339 RPL15P1 20p11.23 ribosomal protein L15 pseudogene 1 CSRP2BP 20p11.23 CSRP2 binding protein ZNF133 20p11.23-p11.22 zinc finger protein 133 (clone pHZ-13) C20orf12 20p11.23 chromosome 20 open reading frame 12 POLR3F 20p11.23 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa RBBP9 20p11.2 retinoblastoma binding protein 9 RPS19P1 20p11.23 ribosomal protein S19 pseudogene 1 SEC23B 20pter-p12.3 Sec23 homolog B (S. cerevisiae) LOC388789 20 hypothetical gene supported by AF147354 HARS2 20p11.23 histidyl-tRNA synthetase 2 HSPC072 20p11.23 HSPC072 protein C20orf78 20p11.23 chromosome 20 open reading frame 78 C20orf79 20 chromosome 20 open reading frame 79 SLC24A3 20p13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 LOC388790 20 LOC388790 RPL12L3 20p11.22 ribosomal protein L12-like 3
    RNA
    TRANSCRIPTS type messenger
    text all transcripts encode the same isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 3429 86 767 - 1996 8898360
    20 splicing 3447 86 767 - 1996 8898360
    20 splicing 3126 86 767 - 1996 8898360
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerythroid
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to yeast Sec23p
    homolog to C.elegans Y113G7A.3
    Homologene
    FAMILY
  • SEC23/SEC24 family (a component of the COPII coat protein complex)
  • SEC23 subfamily
  • CATEGORY secretory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in protein transport through membrane vesicles (Bianchi 2009)
  • with SEC23A, although highly related paralogous secretory COPII components, are nonredundant in erythrocyte maturation (Schwarz 2009)
  • core component of coat protein complex II-coated vesicles, which transport secretory proteins from the endoplasmic reticulum to the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular transport from the endoplasmic reticulum to the Golgi apparatus
    PATHWAY
    metabolism
    signaling
    a component
  • component of COPII coat
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC13/31 complex
  • SAR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDAN2 , CWS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SEC23B-deficient mice die perinatally, exhibiting massive pancreatic degeneration, with this early mortality limiting evaluation of the adult hematopoietic compartment, but SEC23B-deficient hematopoietic stem cells (HSC) do not exhibit a disadvantage at reconstituting hematopoiesis when compared directly to wild-type HSC in a competitive repopulation assay