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FLASH GENE
Symbol SEC23B contributors: mct/npt - updated : 04-12-2015
HGNC name Sec23 homolog B (S. cerevisiae)
HGNC id 10702
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast Sec23p
homolog to C.elegans Y113G7A.3
Homologene
FAMILY
  • SEC23/SEC24 family (a component of the COPII coat protein complex)
  • SEC23 subfamily
  • CATEGORY secretory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in protein transport through membrane vesicles (Bianchi 2009)
  • with SEC23A, although highly related paralogous secretory COPII components, are nonredundant in erythrocyte maturation (Schwarz 2009)
  • core component of coat protein complex II-coated vesicles, which transport secretory proteins from the endoplasmic reticulum to the Golgi apparatus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular transport from the endoplasmic reticulum to the Golgi apparatus
    PATHWAY
    metabolism
    signaling
    a component
  • component of COPII coat
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC13/31 complex
  • SAR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDAN2 , CWS7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • SEC23B-deficient mice die perinatally, exhibiting massive pancreatic degeneration, with this early mortality limiting evaluation of the adult hematopoietic compartment, but SEC23B-deficient hematopoietic stem cells (HSC) do not exhibit a disadvantage at reconstituting hematopoiesis when compared directly to wild-type HSC in a competitive repopulation assay