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FLASH GENE

Symbol

SEC14L4

contributors: mct - updated : 01-03-2011

HGNC name	SEC14-like 4 (S. cerevisiae)
HGNC id	20627

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q12.1      Physical location : 30.884.897 - 30.901.698
Synonym name	SEC14p-like protein TAP3
Synonym symbol(s)	TAP3, dJ130H16.5

DNA

TYPE	functioning gene
STRUCTURE	16.81 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

within 160kb with TAP1 and TAP2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001161368 12 - 2158 - 360 - 2010 20012369 NM_174977 12 - 2526 - 406 - 2010 20012369

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           liver         Homo sapiens Endocrine adrenal gland         Homo sapiens Nervous brain hindbrain cerebellum     Homo sapiens Respiratory lung       highly Homo sapiens Skin/Tegument skin

cell lineage
cell lines	STTG, T/G, H441 cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SEC14-like domain
	one CRAL-TRIO domain
	one GOLD domain

HOMOLOGY

interspecies

homolog to murine Sec14l4

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,nucleus
text	partially located to ER and Golgi
	in the perinuclear region

basic FUNCTION	may be a phosphatidylinositol transfer protein to organelles
	may be involved in the assembly of secretory granules
	may modulate phosphatidyl-inositol-3-kinase, in a tocopherol-sensitive manner
	may participate in intracellular lipid transport (phospholipids, squalene, tocopherol analogues and derivatives) or influence regulatory lipid-dependent events
	may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites
	may participate in intracellular lipid transport and influence regulatory lipid-dependent events

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	lipid binding (tocopherol, phosphatidylinositol, phosphatidylcholine,phosphatidylglycerol)

protein

cell & other

REGULATION

Other

up-regulated during differentiation or stimulated by 9-cis-retinoic-acid

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS