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FLASH GENE
Symbol SEC14L4 contributors: mct - updated : 01-03-2011
HGNC name SEC14-like 4 (S. cerevisiae)
HGNC id 20627
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SEC14-like domain
  • one CRAL-TRIO domain
  • one GOLD domain
  • HOMOLOGY
    interspecies homolog to murine Sec14l4
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    text
  • partially located to ER and Golgi
  • in the perinuclear region
  • basic FUNCTION
  • may be a phosphatidylinositol transfer protein to organelles
  • may be involved in the assembly of secretory granules
  • may modulate phosphatidyl-inositol-3-kinase, in a tocopherol-sensitive manner
  • may participate in intracellular lipid transport (phospholipids, squalene, tocopherol analogues and derivatives) or influence regulatory lipid-dependent events
  • may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites
  • may participate in intracellular lipid transport and influence regulatory lipid-dependent events
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
    lipid binding (tocopherol, phosphatidylinositol, phosphatidylcholine,phosphatidylglycerol)
    protein
    cell & other
    REGULATION
    Other up-regulated during differentiation or stimulated by 9-cis-retinoic-acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS