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FLASH GENE
Symbol SDHAF1 contributors: mct/npt - updated : 26-09-2009
HGNC name succinate dehydrogenase complex assembly factor 1
HGNC id 33867
Corresponding disease
SDHAF1D succinate dehydrogenase complex assembly factor 1 deficiency
Location 19q13.12      Physical location : 36.486.089 - 36.487.221
Synonym name hypothetical protein LOC644096
Synonym symbol(s) LOC644096
DNA
TYPE functioning gene
STRUCTURE 1.11 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1131 - 115 - Ghezzi (2009)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a LYR tripeptide motif (may be a signature for proteins involved in Fe-S metabolism), which is present in the N-terminal region of several protein sequences in different species (Ghezzi 2009)
    • HOMOLOGY
    Homologene
    FAMILY
  • complex I LYR family
  • SDHAF1 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text translocated by the proton motive–dependent transport system into the inner mitochondrial compartment (Ghezzi 2009)
    basic FUNCTION
  • only protein so far identified with a specific role for complex II, as other Fe-S–dependent activities were normal in SDHAF1-defective organisms, including CI and complex III (Ghezzi 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SDHAF1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS