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FLASH GENE
Symbol SDC3 contributors: mct - updated : 26 -08 -20
HGNC name syndecan 3 (N-syndecan)
HGNC id 10660
Location 1p35.2      Physical location : 31.342.312 - 31.381.480
Synonym symbol(s) SDCN, SYND3, KIAA0468
DNA
TYPE functioning gene
STRUCTURE 39.17 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391025 1 similar to protein tyrosine phosphatase, receptor type, U isoform 2 precursor; protein tyrosine phosphatase J; protein tyrosine phosphatase receptor omicron; pi R-PTP-Psi LOC388614 1 LOC388614 LOC388615 1 LOC388615 MATN1 1p35.1-p34.3 matrilin 1, cartilage matrix protein LAPTM5 1p34 matrilin 1, cartilage matrix protein LOC388616 1 LOC388616 SDC3 1pter-p22.3 syndecan 3 (N-syndecan) PUM1 1p35.2 pumilio homolog 1 (Drosophila) SEPW1P 1p34-p35 selenoprotein W, 1 pseudogene FLJ12650 1p35.1 hypothetical protein FLJ12650 HPRP8BP 1p35.1 U5 snRNP-specific 40 kDa protein (hPrp8-binding) PS1D 1p35.1 putative S1 RNA binding domain protein FABP3 1p33-p32 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) TDE2L 1p35.1 tumor differentially expressed 2-like LOC127572 1p35.1 similar to elongation factor 1 alpha LOC149086 1p35.1 hypothetical protein LOC149086 LCN7 1p34.3 lipocalin 7 HCRTR1 1p33 hypocretin (orexin) receptor 1 PEF 1p34 hypocretin (orexin) receptor 1 COL16A1 1p34.3 collagen, type XVI, alpha 1 BAI2 1p35 brain-specific angiogenesis inhibitor 2 FLJ25348 1p35.1 hypothetical protein FLJ25348 PTP4A2 1p36 protein tyrosine phosphatase type IVA, member 2 KHDRBS1 1p32 KH domain containing, RNA binding, signal transduction associated 1 FLJ10315 1p34.3 hypothetical protein FLJ10315 KPNA6 1p35-p34.1 karyopherin alpha 6 (importin alpha 7) DKFZp451J0118 1p34.3 taxilin
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5121 - 442 - 2011 21200028
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta   
Digestiveintestinelarge intestinecolon  
 stomach    
Endocrineadrenal gland    
Lymphoid/Immunespleen    
Nervousbrain    
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular domain with eight glycosaminoglycan attachment sites arranged in two clusters
  • an intracellular domain with a PDZ domain-interacting motif and four conserved tyrosine residues
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • playing a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent
  • regulator of the mitotic behavior of chondrocytes
  • may be involving formation of dimeric/oligomeric structures on their cell surface
  • with SDC4,function as coreceptors for tyrosine kinases and in cell adhesion
  • novel regulator of feeding behavior and body weight, having a potential role as a modulator of gonadal steroid function
  • Syndecan-3 and NOTCH1 cooperate in regulating homeostasis of the satellite cell population and myofiber size
  • may directly transduce GDNF family ligands (GFLs) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET
  • CELLULAR PROCESS cell life
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NOTCH1 and is required for NOTCH1 processing by ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and signal transduction
  • GDNF family ligands (GFLs)-syndecan-3 interaction mediates both cell spreading and neurite outgrowth with the involvement of Src kinase activation
  • cell & other
  • major HIV-1 attachment receptor on dendritic cells (DC) (is a DC-specific heparan sulfate (HS) proteoglycan that captures HIV-1 through interaction with the HIV-1 envelope glycoprotein gp120) (
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyimmunodeficiency 
    an effective microbicide should target both syndecan-3 and CD209 on dendritic cells to prevent HIV transmission
    ANIMAL & CELL MODELS
    Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells