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FLASH GENE

Symbol

SDC3

contributors: mct - updated : 26 -08 -20

HGNC name	syndecan 3 (N-syndecan)
HGNC id	10660

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p35.2      Physical location : 31.342.312 - 31.381.480
Synonym symbol(s)	SDCN, SYND3, KIAA0468

DNA

TYPE	functioning gene
STRUCTURE	39.17 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014654 5 - 5121 - 442 - 2011 21200028

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel aorta       Digestive intestine large intestine colon       stomach         Endocrine adrenal gland         Lymphoid/Immune spleen         Nervous brain

cells

System Cell Pubmed Species Stage Rna symbol not specific chondrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an extracellular domain with eight glycosaminoglycan attachment sites arranged in two clusters
	an intracellular domain with a PDZ domain-interacting motif and four conserved tyrosine residues

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION	playing a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent
	regulator of the mitotic behavior of chondrocytes
	may be involving formation of dimeric/oligomeric structures on their cell surface
	with SDC4,function as coreceptors for tyrosine kinases and in cell adhesion
	novel regulator of feeding behavior and body weight, having a potential role as a modulator of gonadal steroid function
	Syndecan-3 and NOTCH1 cooperate in regulating homeostasis of the satellite cell population and myofiber size
	may directly transduce GDNF family ligands (GFLs) signals or serve as a coreceptor, presenting GFLs to the signaling receptor RET

CELLULAR PROCESS	cell life
	cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with NOTCH1 and is required for NOTCH1 processing by ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and signal transduction
	GDNF family ligands (GFLs)-syndecan-3 interaction mediates both cell spreading and neurite outgrowth with the involvement of Src kinase activation

cell & other	major HIV-1 attachment receptor on dendritic cells (DC) (is a DC-specific heparan sulfate (HS) proteoglycan that captures HIV-1 through interaction with the HIV-1 envelope glycoprotein gp120) (

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology immunodeficiency   an effective microbicide should target both syndecan-3 and CD209 on dendritic cells to prevent HIV transmission

ANIMAL & CELL MODELS

Syndecan-3(-/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells