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FLASH GENE
Symbol SCG5 contributors: mct/npt - updated : 26-08-2014
HGNC name secretogranin V (7B2 protein)
HGNC id 10816
Location 15q13.3      Physical location : 32.933.869 - 32.989.298
Synonym name
  • pituitary polypeptide 7B2
  • secretory granule, neuroendocrine protein 1 (7B2 protein)
  • prohormone convertase chaperone
    • Synonym symbol(s) P7B2, SGNE1, 7B2, SgV
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    STRUCTURE 55.43 kb     6 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure a CpG island within the 5prime region and untranslated first exon that showed hypermethylation in medulloblastomas compared to fetal cerebellum (Waha 2007)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1244 - 212 - 2007 17334394
    6 - 1241 - 211 - 2007 17334394
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrine     Homo sapiens
     pancreas   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal peptide that can inhibit PC2 and may contribute to keep the enzyme transiently inactive (Mbikay 2001)
    • HOMOLOGY
    interspecies homolog to rattus Sgne1
    ortholog to murine Sgne1
    homolog to Xenopus Xl.1105
    homolog to zebrafish Dr.12487
    homolog to C.elegans R07E3.7
    Homologene
    FAMILY
  • granin family of proteins
    • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text neuroendocrine and endocrine secretory granules
    basic FUNCTION
  • acting as a enzyme activator
  • acting as a specific chaperone for proprotein convertase-2 (PC2)
  • acidic protein residing in the secretory granules of neuroendocrine cells (Mbikay 2001)
  • regulator/activator of the prohormone convertase 2 which is involved in the processing of numerous neuropeptides, including insulin, glucagon and pro-opiomelanocortin
  • role for SCG5 in the modulation of body weight
  • PCSK2 requires interaction with the neuroendocrine protein SCG5 for the production of an activatable zymogen
  • can also act as a postfolding chaperone to block the aggregation of a number of other proteins, for example, SNCA
  • is a natively disordered protein whose function as an antiaggregant chaperone is likely facilitated by its lack of appreciable secondary structure and tendency to form oligomers
  • is a novel anti-aggregation secretory chaperone associated with neurodegenerative disease
  • likely playing a role in the etiology of aggregate formation in neurodegenerative disease
  • neuronal SCG5 could function to block neurodegenerative disease-related protein aggregation
  • SCG5 and PCSK1N may perform a chaperone role as secretory anti-aggregants in normal islet cell function and in type 2 diabetes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    neuropeptide signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
  • required for the production of active prohormone convertase 2 (PCSK2), an enzyme involved in the synthesis of peptide hormones, such as glucagon and POMC
  • is a prohormone convertase 2 (PCSK2)-binding protein
  • it is possible that SCG5 acts via similar molecular mechanisms to decrease APP protein oligomerization, fibrillation, and cytotoxicity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    silenced gene in medulloblastomas (Waha 2007)
    constitutional     --over  
    in brain tissues of AD patients, and in the cerebrospinal fluid of amyotrophic lateral sclerosis patients
    tumoral     --low  
    silenced by DNA methylation in astrocytic gliomas
    Susceptibility
  • to glucoise intolerance in obesity
  • to colorectal cancer (CRC)
    • Variant & Polymorphism SNP
  • SNP -1,701A>G did not associate with risk of T2D but tends to associate with incidence of type 2 diabetes (may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity) (Bouatia-Naji 2007)
  • SNPs near SCG5 were strongly associated with increased CRC risk (Jaeger 2008)
    • Candidate gene good marker of several neuroendocrine cell dysfunctions (Mbikay 2001)
    Marker
    Therapy target
    ANIMAL & CELL MODELS