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FLASH GENE
Symbol SARDH contributors: mct - updated : 09-11-2018
HGNC name sarcosine dehydrogenase
HGNC id 10536
Corresponding disease
SARDH sarcosinemia
Location 9q34.2      Physical location : 136.528.685 - 136.605.077
Synonym name
  • sarcosine dehydrogenase, mitochondrial
  • dimethylglycine dehydrogenase-like 1
  • Synonym symbol(s) SDH, SAR, DMGDHL1, BPR-2, SARD
    EC.number 1.5.99.1
    DNA
    TYPE functioning gene
    STRUCTURE 76.40 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status tentative : very preliminary evidence
    Physical map
    GFI1B 9q34.13 growth factor independent 1B (potential regulator of CDKN1A, translocated in CML) LOC158078 9q34 eukaryotic translation elongation factor 1 alpha 1 pseudogene LOC389801 9 LOC389801 GTF3C5 9q34 general transcription factor IIIC, polypeptide 5, 63kDa CEL 9q34.2 carboxyl ester lipase (bile salt-stimulated lipase) CELP 9q34.2-q34.3 carboxyl ester lipase pseudogene RALGDS 9q34.1-q34.2 ral guanine nucleotide dissociation stimulator FS 9q34 ral guanine nucleotide dissociation stimulator OBP2B 9q34 ral guanine nucleotide dissociation stimulator LOC286310 9q34.3 similar to Von Ebners gland protein precursor (VEG protein) (Tear prealbumin) (TP) (Tear lipocalin) (Lipocalin 1) ABO 9q34.1-q34.2 ABO blood group (transferase A, aplha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3galactosyltransferase) LOC392396 9 similar to Von Ebners gland protein precursor (VEG protein) (Tear prealbumin) (TP) (Tear lipocalin) (Lipocalin 1) SURF6 9q34.2 surfeit 6 SURF5 9q34.2 surfeit 5 RPL7A 9q34.2 ribosomal protein L7a SURF1 9q34.2 surfeit 1 SURF2 9q34.2 surfeit 2 SURF4 9q34.2 surfeit 4 ADAMTS13 9q34 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 C9orf7 9q34 chromosome 9 open reading frame 7 SLC2A6 9q34 solute carrier family 2 (facilitated glucose transporter), member 6 DBH 9q34.2 dopamine beta-hydroxylase (dopamine beta-monooxygenase) SARDH 9q33-q34 sarcosine dehydrogenase VAV2 9q34.2 vav 2 oncogene LOC389803 9 similar to bA74P14.2 (novel protein) BRD3 9q34.2-q34.3 bromodomain containing 3 ARF4P 9q34 ADP-ribosylation factor 4 pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3234 - 918 - -
    21 - 3398 - 918 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alternate polyadenylation and splices sites
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • gcvT family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • essentially a mitochondrial enzyme, but it can also be found in the cytosol and/or the Golgi apparatus, where it could be interacting with TMEFF2 during trafficking
  • basic FUNCTION
  • sarcosine dehydrogenase, catalyzing glycine synthesis, "one-carbone" metabolism, flavoenzyme
  • responsible for conversion of sarcosine to glycine and is therefore one of the regulators of sarcosine levels in the cell
  • plays an important role in the conversion of sarcosine to glycine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of SARDH with TMEFF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SARDH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS