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FLASH GENE
Symbol SARDH contributors: mct - updated : 09-11-2018
HGNC name sarcosine dehydrogenase
HGNC id 10536
Corresponding disease
SARDH sarcosinemia
Location 9q34.2      Physical location : 136.528.685 - 136.605.077
Synonym name
  • sarcosine dehydrogenase, mitochondrial
  • dimethylglycine dehydrogenase-like 1
    • Synonym symbol(s) SDH, SAR, DMGDHL1, BPR-2, SARD
    EC.number 1.5.99.1
    DNA
    TYPE functioning gene
    STRUCTURE 76.40 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status tentative : very preliminary evidence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 3234 - 918 - -
    21 - 3398 - 918 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alternate polyadenylation and splices sites
    • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • gcvT family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • essentially a mitochondrial enzyme, but it can also be found in the cytosol and/or the Golgi apparatus, where it could be interacting with TMEFF2 during trafficking
    • basic FUNCTION
  • sarcosine dehydrogenase, catalyzing glycine synthesis, "one-carbone" metabolism, flavoenzyme
  • responsible for conversion of sarcosine to glycine and is therefore one of the regulators of sarcosine levels in the cell
  • plays an important role in the conversion of sarcosine to glycine
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of SARDH with TMEFF2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SARDH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS