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FLASH GENE
Symbol SARDH contributors: mct - updated : 09-11-2018
HGNC name sarcosine dehydrogenase
HGNC id 10536
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3234 - 918 - -
21 - 3398 - 918 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • alternate polyadenylation and splices sites
  • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • gcvT family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • essentially a mitochondrial enzyme, but it can also be found in the cytosol and/or the Golgi apparatus, where it could be interacting with TMEFF2 during trafficking
  • basic FUNCTION
  • sarcosine dehydrogenase, catalyzing glycine synthesis, "one-carbone" metabolism, flavoenzyme
  • responsible for conversion of sarcosine to glycine and is therefore one of the regulators of sarcosine levels in the cell
  • plays an important role in the conversion of sarcosine to glycine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of SARDH with TMEFF2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SARDH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS