basic FUNCTION
| involved in zinc-ion homeostasis by zinc-responsive transcriptonal regulation |
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plays positive roles in the generation of pluripotent stem cells from blastocysts and fibroblasts |
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modulates stem cell pluripotency and self-renewal capability in embryonic development and also plays a role in leukemogenesis |
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plays a central role in embryonic and leukemic stem cells |
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novel role for SALL4 in drug sensitivity, at least in part through the maintenance of side population cells, and therefore may be responsible for drug-resistance in leukemia |
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robust stimulator for the expansion of hematopoietic stem cells |
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key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells |
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stem cell protein, playing a vital role in maintaining stem cell identity and governing stem cell self-renewal through transcriptional repression |
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auto- and cross-regulation of CDX4 and SALL4 establish a stable molecular circuit in the mesoderm that facilitates the activation of the blood-specific program as development proceeds |
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is a transcription factor that enhances proliferation and migration in breast cancer cells |