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FLASH GENE
Symbol SALL4 contributors: mct/ - updated : 13-06-2015
HGNC name sal-like 4 (Drosophila)
HGNC id 15924
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Reproductivefemale systemovary   
 male systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
cell lineage progenitor of mesodermal lineage (MPCs)
cell lines pheochromocytoma cell lines
fluid/secretion
at STAGE
physiological period fetal
Text heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight C2H2 double zinc finger motifs
  • HOMOLOGY
    interspecies ortholog to murine Sall4
    intraspecies homolog to SALL3
    Homologene
    FAMILY
  • sal C2H2-type zinc-finger protein family
  • CATEGORY transcription factor , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    basic FUNCTION
  • involved in zinc-ion homeostasis by zinc-responsive transcriptonal regulation
  • plays positive roles in the generation of pluripotent stem cells from blastocysts and fibroblasts
  • modulates stem cell pluripotency and self-renewal capability in embryonic development and also plays a role in leukemogenesis
  • plays a central role in embryonic and leukemic stem cells
  • novel role for SALL4 in drug sensitivity, at least in part through the maintenance of side population cells, and therefore may be responsible for drug-resistance in leukemia
  • robust stimulator for the expansion of hematopoietic stem cells
  • key factor for the maintenance of pluripotency and self-renewal of embryonic stem cells
  • stem cell protein, playing a vital role in maintaining stem cell identity and governing stem cell self-renewal through transcriptional repression
  • auto- and cross-regulation of CDX4 and SALL4 establish a stable molecular circuit in the mesoderm that facilitates the activation of the blood-specific program as development proceeds
  • is a transcription factor that enhances proliferation and migration in breast cancer cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • link between SALL4 and BMI1 in regulating self-renewal of normal and leukemic stem cells (potential role for a SALL4/BMI1 network in leukemogenesis)
  • DNMTs and histone deacetylase repressors synergistically contribute to the regulatory effects of SALL4
  • mechanistically, SALL4 sequesters ZBTB16 to noncognate chromatin domains to induce expression of KIT, a target of ZBTB16-mediated repression required for differentiation
  • CDX1-induced SALL4 and KLF5 converted gastric epithelial cells into tissue stem-like progenitor cells, which then transdifferentiated into intestinal epithelial cell
  • TRIM21 is likely involved in nuclear SALL4 degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DRRS , OORS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    mRNA overexpression essential for embryonic development and the self-renewal of embryonic stem cells, in lung cancer
    tumoral     --over  
    causing the aberrant activation of the Wnt/beta-catenin pathway in myelodysplastic syndromes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • sensitive diagnostic marker for primary germ cell tumors of the CNS with high specificity, and is a more sensitive marker than alpha-fetoprotein and glypican-3 for yolk sac tumors
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    leukemia stem cell-specific therapy by targeting SALL4
    ANIMAL & CELL MODELS