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FLASH GENE
Symbol SACM1L contributors: mct - updated : 01-06-2011
HGNC name SAC1 suppressor of actin mutations 1-like (yeast)
HGNC id 17059
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3707 67 587 - 2000 10887188
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum highly
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • integral membrane protein of the endoplasmic reticulum and the Golgi complex
  • basic FUNCTION
  • possibility that the enzymatic function of SACM1L provides a switch for accessibility of the COPI interaction motif
  • direct roles for MAPK14 and SACM1L in transmitting growth signals to the secretory machinery
  • in quiescent cells stimulated by mitogens, rapidly shuttles back to the endoplasmic reticulum (ER), thus releasing the brake on Golgi secretion
  • executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles and both enzymatic activity and endoplasmic reticulum localization are important SACM1L functional properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • members of the coatomer I (COPI) complex as interaction partners of SACM1L
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS