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FLASH GENE
Symbol S1PR5 contributors: mct - updated : 17-09-2013
HGNC name sphingosine-1-phosphate receptor 5
HGNC id 14299
Location 19p13.2      Physical location : 10.623.418 - 10.628.668
Synonym name
  • sphingosine 1-phosphate receptor Edg-8
  • sphingosine 1-phosphate receptor 5
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
    • Synonym symbol(s) SPPR-1, SPPR-2 , S1P5, EDG8
    DNA
    TYPE functioning gene
    STRUCTURE 5.25 kb     2 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 splicing 2194 41.8 398 - Grimwood (2004)
    SPPR
    2 splicing 2351 - 398 - Kothapalli (unpublished)
    SPPR-1
    2 splicing 1250 10.9 103 - Kothapalli (unpublished)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vesselsaorta   
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
    Nervousbrainbasal nucleicorpus callosum highly
    Reproductivemale systemprostate   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticmonocyte
    Nervousneuron Mus musculusAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text tissues, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to Drosophila CG1062
    homolog to C.elegans C40C9.5
    ortholog to rat Edg8
    Homologene
    FAMILY
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • localised in the centrosome of mammalian cells
    • basic FUNCTION
  • may be involved in the processes that regulate the differentiation of endothelial cells
  • may potentially function as a ligand activated GEF in regulating G-protein-dependent spindle formation and mitosis
  • in brain endothelial cells, contributes to optimal barrier formation and maintenance of immune quiescence of the barrier endothelium
  • regulates potentially the trafficking of monocytes via a mechanism independent of S1P gradients
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coordinated changes in CXCR4 and S1PR5 responsiveness govern NK-cell trafficking
    • cell & other
  • SIP
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in large granular lymphocyte (LGL) leukemia
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS