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FLASH GENE
Symbol S1PR5 contributors: mct - updated : 17-09-2013
HGNC name sphingosine-1-phosphate receptor 5
HGNC id 14299
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 splicing 2194 41.8 398 - Grimwood (2004)
SPPR
2 splicing 2351 - 398 - Kothapalli (unpublished)
SPPR-1
2 splicing 1250 10.9 103 - Kothapalli (unpublished)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vesselsaorta   
Digestivesalivary gland   highly
Lymphoid/Immunespleen   highly
Nervousbrainbasal nucleicorpus callosum highly
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticmonocyte
Nervousneuron Mus musculusAdult
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text tissues, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila CG1062
homolog to C.elegans C40C9.5
ortholog to rat Edg8
Homologene
FAMILY
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text
  • localised in the centrosome of mammalian cells
  • basic FUNCTION
  • may be involved in the processes that regulate the differentiation of endothelial cells
  • may potentially function as a ligand activated GEF in regulating G-protein-dependent spindle formation and mitosis
  • in brain endothelial cells, contributes to optimal barrier formation and maintenance of immune quiescence of the barrier endothelium
  • regulates potentially the trafficking of monocytes via a mechanism independent of S1P gradients
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coordinated changes in CXCR4 and S1PR5 responsiveness govern NK-cell trafficking
  • cell & other
  • SIP
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in large granular lymphocyte (LGL) leukemia
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS