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FLASH GENE
Symbol S100P contributors: mct - updated : 02-02-2011
HGNC name S100 calcium binding protein P
HGNC id 10504
Location 4p16.1      Physical location : 6.695.565 - 6.698.896
Synonym name
  • migration-inducing gene 9
  • protein S100-E
  • Synonym symbol(s) S100E, MIG9
    DNA
    TYPE functioning gene
    STRUCTURE 3.33 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MSX1 4p16.3-p16.1 msh homeo box homolog 1 (Drosophila) LDHAL1 4p16.3-p15.3 lactate dehydrogenase A-like 1 LOC132870 4p16.2 hypothetical gene LOC132870 C17 4p16-p15 hypothetical gene LOC132870 HSA250839 4p16.2 gene for serine/threonine protein kinase C4orf6 4p16 chromosome 4 open reading frame 6 EVC2 4p16.2-p16.1 Ellis van Creveld syndrome 2 (limbin) EVC 4p16 Ellis van Creveld syndrome CRMP1 4p16.1-p15 collapsin response mediator protein 1 LOC389197 4 hypothetical gene supported by BX648674 FLJ31564 LOC389198 4 LOC389198 WFS1 4p16.1 Wolfram syndrome 1 (wolframin) PPP2R2C 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform KIAA0935 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform PGR1 4p16.1 T-cell activation protein LOC93622 4p16.1 hypothetical protein BC006130 S100P 4p16 S100 calcium binding protein P MGC9651 4p16.1 hypothetical protein MGC9651 CNO 4p16.1 cappuccino KIAA0232 4p16.1 KIAA0232 gene product KIAA1322 FLJ90575 4p16.1 hypothetical protein FLJ90575 MGC21874 4p16.1 transcriptional adaptor 2 (ADA2 homolog, yeast)-beta GRPEL1 4p16 GrpE-like 1, mitochondrial (E. coli) SORCS2 4p16 GrpE-like 1, mitochondrial (E. coli) AFAP 4p16 actin filament associated protein MGC10981 4p16.1 hypothetical protein MGC10981 LOC389199 4 hypothetical gene supported by BC031673 ABLIM2 4p16-p15 actin binding LIM protein 2 LOC391618 4 hypothetical gene supported by NM_003875 FLJ20356 HTRA3 4p16.1 serine protease HTRA3 ACOX3 4p15.3 acyl-Coenzyme A oxidase 3, pristanoyl FLJ35725 4p16.1 hypothetical protein FLJ35725 FLJ12891 4p16.1 hypothetical protein FLJ12891 GPR78 4p16.1 G protein-coupled receptor 78 CPZ 4p16 carboxypeptidase Z
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 510 - 95 - 1992 1633809
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     stomach    
    Reproductivefemale systemuteruscervix  
    Respiratorylung    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand calcium binding motifs
  • AAs 2125 of the first EF hand of S100P as important for IQGAP1 binding
  • HOMOLOGY
    Homologene
    FAMILY
  • S100 protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in cell cycle progression and differentiation
  • can activate the membrane and F-actin binding protein ezrin in a Ca2+ dependent manner
  • affects apoptosis, cell growth, and invasion through either an intracellular or an extracellular mechanism
  • Ca2+-dependent regulator of IQGAP1 that can down-regulate the function of IQGAP1 as a signaling intermediate by direct interaction
  • appears to regulate only a set of IQGAP1-target protein interactions in response to intracellular Ca2+ transients
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IQGAP1 (binding occurs primarily through the IQ domain of IQGAP1 and the first EF hand loop of S100P)
  • cell & other
    REGULATION
    activated by non-steroidal anti-inflammatory drugs, which reduces their anti-tumorigenic activity
    Other regulated by PORCN (might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma)
    regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypomethylation in prostate cancer (Wang 2007)
    tumoral     --low  
    in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role
    tumoral     --over  
    in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS