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FLASH GENE
Symbol S100P contributors: mct - updated : 24-03-2020
HGNC name S100 calcium binding protein P
HGNC id 10504
Location 4p16.1      Physical location : 6.695.565 - 6.698.896
Synonym name
  • migration-inducing gene 9
  • protein S100-E
    • Synonym symbol(s) S100E, MIG9
    DNA
    TYPE functioning gene
    STRUCTURE 3.29 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 510 - 95 - 1992 1633809
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     stomach    
    Reproductivefemale systemuteruscervix  
    Respiratorylung    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta and is expressed in trophoblasts, the highest expression levels occurring during the first trimester of gestation, particularly in the invading columns and anchoring villi
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one classical EF-hand Ca2+-binding domain and an atypical EF-hand domain
  • AAs 21–25 of the first EF hand of S100P as important for IQGAP1 binding
  • C-terminal lysine residue, and strong, C-terminal lysine-dependent activation of tissue plasminogen activator (PLAT), but not of urokinase-catalysed plasminogen activation
    • mono polymer monomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • S100 protein family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • involved in cell cycle progression and differentiation
  • can activate the membrane and F-actin binding protein ezrin in a Ca2+ dependent manner
  • affects apoptosis, cell growth, and invasion through either an intracellular or an extracellular mechanism
  • Ca2+-dependent regulator of IQGAP1 that can down-regulate the function of IQGAP1 as a signaling intermediate by direct interaction
  • appears to regulate only a set of IQGAP1-target protein interactions in response to intracellular Ca2+ transients
  • S100P participates in the periodic change of the endometrium under the regulation of progesterone
  • may have a physiological role in normal pregnant development, and regulate trophoblast-like cell proliferation via modulating the MAPK14 pathway
  • Ca2+ binding protein, overexpressed in various cancers, that increases cancer migration, invasion and metastasis in lung cancer cells
  • is a small calcium-binding protein in the S100 protein family that regulates cellular, physiological and pathological processes in various cancers
  • S100P may be acting as an important regulator of trophoblast invasion during placentation
  • S100P and EZR promote trans-endothelial migration of triple negative breast cancer cells
  • contribute to a cancer pathway dependent on the context of CDH1 function
  • S100P has a dual role in gastric cancer, acting as an oncogenic factor in the context of CDH1 loss and as a tumour suppressor in a functional CDH1 setting
    • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • both dimeric and monomeric forms of S100P can be functional
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with IQGAP1 (binding occurs primarily through the IQ domain of IQGAP1 and the first EF hand loop of S100P)
  • S100P dissociates MYH9 filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration
  • SOX9 promotes tumor metastasis and invasion through regulation of S100P expression
  • interacts with ITGA7 and increases cancer cell migration and invasion in lung cancer
  • LASP1 may act as an oncogene to regulate the expression of S100P to influence cellular functions in gallbladder cancer (GBC)
  • S100P protein interacts with interferon beta (IFNB1) depending on calcium level and oligomeric state of S100P
  • S100P can interact directly with two different cytoskeletal filaments to independently enhance cell migration, the most important step in the metastatic cascade
    • cell & other
    REGULATION
    activated by non-steroidal anti-inflammatory drugs, which reduces their anti-tumorigenic activity
    Other regulated by PORCN (might regulate the expression of some cancer-related molecules including S100P in non-small cell lung carcinoma)
    regulated by bone morphogenetic protein in pancreatic duct epithelial cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    by hypomethylation in prostate cancer (Wang 2007)
    tumoral     --low  
    in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role
    tumoral     --over  
    in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin
    tumoral     --over  
    in human hepatocellular carcinoma (HCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • analysis of S100P concentration in Duodenal Fluid, in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)
  • plasma S100P level is a simple and cost-effective marker for the prognosis of metastatic breast cancer
  • S100P may be regarded as a promising diagnostic marker to Pancreatic cancer screening
  • S100P protein is a novel independent predictor for poor prognosis in HCC
  • may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation
    • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    S100P may be a promising target to inhibit lymph node metastasis
    ANIMAL & CELL MODELS