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FLASH GENE
Symbol S100P contributors: mct - updated : 24-03-2020
HGNC name S100 calcium binding protein P
HGNC id 10504
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
by hypomethylation in prostate cancer (Wang 2007)
tumoral     --low  
in lung adenocarcinomas, at advanced stages seems to be important for tumour progression in which DNA methylation and/or feedback transcription processes play a critical role
tumoral     --over  
in highly metastatic cancers is probably due to a direct interaction between S100P-ezrin
tumoral     --over  
in human hepatocellular carcinoma (HCC)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • analysis of S100P concentration in Duodenal Fluid, in combination with routine screening upper gastrointestinal endoscopy (GIE), may facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)
  • plasma S100P level is a simple and cost-effective marker for the prognosis of metastatic breast cancer
  • S100P may be regarded as a promising diagnostic marker to Pancreatic cancer screening
  • S100P protein is a novel independent predictor for poor prognosis in HCC
  • may be used as a unique biomarker of the receptive endometrium and play an important role in embryo implantation
  • Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    S100P may be a promising target to inhibit lymph node metastasis
    ANIMAL & CELL MODELS