Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RXRB contributors: mct/npt - updated : 05-04-2019
HGNC name retinoid X receptor, beta
HGNC id 10478
Location 6p21.3      Physical location : 4.393.587 - 33.168.432
Synonym name
  • MHC class I promoter binding protein
  • nuclear receptor subfamily 2 group B member 2
  • Synonym symbol(s) NR2B2, DAUDI6, H-2RIIBP, RCoR-1, MGC1831
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text located just upstream of the alpha2(XI) collagen chain gene (Col11a2) in a head-to-tail manner (Murai 2008)
    STRUCTURE 7.07 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • potential presence of enhancer-blocking elements that insulate RXRB promoter from the COL11A2 enhancer (Murai 2008)
  • MAPPING cloned Y linked N status confirmed
    Map see KE@
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2892 - 533 - Fleischhauer (1992)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain
  • a central bipartite (class II) zinc finger DNA binding domain
  • a C terminal ligand domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Rxrb
    Homologene
    FAMILY
  • nuclear hormone receptor family
  • nr2 subfamily
  • CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mediating the effects of retinoic acid (RA)
  • RXRB heterodimerized with aretinoic acid (RA) receptor-alpha (RARA) transduces signals required in Sertoli cells for spermatid release (Vernet 2008)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • obligate member of heterodimeric nuclear receptors
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • retinoic acid X receptor binding
  • cell & other
    REGULATION
    activated by 9-cis-retinoic acid,only (9-cis-RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Wegener Granulomatosis
    Variant & Polymorphism other strong association of the RXRB locus with Wegener Granulomatosis (Wieczorek 2009)
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760)
    ANIMAL & CELL MODELS