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FLASH GENE
Symbol RXRB contributors: mct/npt - updated : 05-04-2019
HGNC name retinoid X receptor, beta
HGNC id 10478
Location 6p21.3      Physical location : 4.393.587 - 33.168.432
Synonym name
  • MHC class I promoter binding protein
  • nuclear receptor subfamily 2 group B member 2
  • Synonym symbol(s) NR2B2, DAUDI6, H-2RIIBP, RCoR-1, MGC1831
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text located just upstream of the alpha2(XI) collagen chain gene (Col11a2) in a head-to-tail manner (Murai 2008)
    STRUCTURE 7.07 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • potential presence of enhancer-blocking elements that insulate RXRB promoter from the COL11A2 enhancer (Murai 2008)
  • MAPPING cloned Y linked N status confirmed
    Map see KE@
    Physical map
    HLA-DMA 6p21.3 major histocompatibility complex, class II, DM alpha BRD2 6p21.3 bromodomain containing 2 HLA-DOA 6p21.3 major histocompatibility complex, class II, DO alpha HLA-DPA1 6p21.3 major histocompatibility complex, class II, DP alpha 1 HLA-DPB1 6p21.3 major histocompatibility complex, class II, DP beta 1 RPL32P1 6p21.3 ribosomal protein L32 pseudogene 1 LOC391913 6 similar to MHC HLA-SX-alpha HLA-DPB2 6p21.3 major histocompatibility complex, class II, DP beta 2 (pseudogene) COL11A2 6p21.3 collagen, type XI, alpha 2 RXRB 6p21.3 retinoid X receptor, beta SLC39A7 6p21.3 solute carrier family 39 (zinc transporter), member 7 HSD17B8 6p21.3 hydroxysteroid (17-beta) dehydrogenase 8 RING1 6p21.3 ring finger protein 1 VPS52 6p21.3 vacuolar protein sorting 52 (yeast) B3GALT4 6p21.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 RPS18 6p21.3 ribosomal protein S18 C6orf11 6p21.3 chromosome 6 open reading frame 11 D6S2723E 6p21.3 DNA segment on chromosome 6 (unique, pseudogene) 2723 expressed sequence HKE2 6p21.3 HLA class II region expressed gene KE2 RAB2L 6p21.3 RAB2, member RAS oncogene family-like TAPBP 6p21.3 TAP binding protein (tapasin) ZNF297 6p21.3 zinc finger protein 297 DAXX 6p21.3 death-associated protein 6 LOC346177 6p21.31 similar to myosin:SUBUNIT=regulatory light chain LYPLA2P1 6p21.31 lysophospholipase II pseudogene 1 KIFC1 6p21.3 kinesin family member C1 PHF1 6p21.3 PHD finger protein 1 C6orf82 6pter-p21.31 chromosome 6 open reading frame 82
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2892 - 533 - Fleischhauer (1992)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain
  • a central bipartite (class II) zinc finger DNA binding domain
  • a C terminal ligand domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Rxrb
    Homologene
    FAMILY
  • nuclear hormone receptor family
  • nr2 subfamily
  • CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mediating the effects of retinoic acid (RA)
  • RXRB heterodimerized with aretinoic acid (RA) receptor-alpha (RARA) transduces signals required in Sertoli cells for spermatid release (Vernet 2008)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • obligate member of heterodimeric nuclear receptors
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • retinoic acid X receptor binding
  • cell & other
    REGULATION
    activated by 9-cis-retinoic acid,only (9-cis-RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Wegener Granulomatosis
    Variant & Polymorphism other strong association of the RXRB locus with Wegener Granulomatosis (Wieczorek 2009)
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760)
    ANIMAL & CELL MODELS