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FLASH GENE
Symbol RXRB contributors: mct/npt - updated : 05-04-2019
HGNC name retinoid X receptor, beta
HGNC id 10478
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal modulator domain
  • a central bipartite (class II) zinc finger DNA binding domain
  • a C terminal ligand domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Rxrb
    Homologene
    FAMILY
  • nuclear hormone receptor family
  • nr2 subfamily
  • CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in mediating the effects of retinoic acid (RA)
  • RXRB heterodimerized with aretinoic acid (RA) receptor-alpha (RARA) transduces signals required in Sertoli cells for spermatid release (Vernet 2008)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • obligate member of heterodimeric nuclear receptors
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • retinoic acid X receptor binding
  • cell & other
    REGULATION
    activated by 9-cis-retinoic acid,only (9-cis-RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Wegener Granulomatosis
    Variant & Polymorphism other strong association of the RXRB locus with Wegener Granulomatosis (Wieczorek 2009)
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    RXRA, RXRB are potential targets for therapy against UV induced melanoma (PMID: 24810760)
    ANIMAL & CELL MODELS