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FLASH GENE
Symbol RTN4IP1 contributors: mct - updated : 09-12-2015
HGNC name reticulon 4 interacting protein 1
HGNC id 18647
Corresponding disease
OPA10 optic atrophy 10
Location 6q21      Physical location : 107.018.904 - 107.077.373
Genatlas name NOGO-interacting mitochondrial protein
Synonym symbol(s) NIMP, MGC12934
DNA
TYPE functioning gene
STRUCTURE 59.47 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391956 6 similar to Hypothetical protein KIAA1002 HACE1 6q21 HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 LOC389420 6 LOC389420 LOC389421 6 similar to LOC373796 protein BVES 6q21 blood vessel epicardial substance POPDC3 6q21 popeye domain containing 3 PREP 6q16.3-q21 prolyl endopeptidase LOC391957 6 similar to Chromatin assembly factor 1 subunit B (CAF-1 subunit B) (Chromatin assembly factor I p60 subunit) (CAF-I 60 kDa subunit) (CAF-Ip60) PRDM1 6q21-q22.1 PR domain containing 1, with ZNF domain APG5L 6q21 APG5 autophagy 5-like (S. cerevisiae) AIM1 6q21 absent in melanoma 1 RTN4IP1 6q21 reticulon 4 interacting protein 1 QRSL1 6q21 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 C6orf203 6q21 chromosome 6 open reading frame 203 KIAA1553 6q21 KIAA1553 C6orf210 6q21 chromosome 6 open reading frame 210 FLJ10159 6q21 hypothetical protein FLJ10159 SCML4 6q21 sex comb on midleg-like 4 (Drosophila) SEC63 6q21 SEC63-like (S. cerevisiae) LOC285752 6q21 similar to ribosomal protein L3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B OSTM1 6q21 osteopetrosis associated transmembrane protein 1 NR2E1 6q21 nuclear receptor subfamily 2, group E, member 1 SNX3 6q13-q22.3 sorting nexin 3 LACE1 6q22.1 lactation elevated 1 FOXO3A 6q21 forkhead box O3A LOC391958 6 similar to zinc finger protein 259; zinc finger protein ZPR1 ARMC2 6q21 armadillo repeat containing 2 SESN1 6q21 sestrin 1 C6orf182 6q21 chromosome 6 open reading frame 182 LOC389422 6 LOC389422 FLJ37396 6q21 hypothetical protein FLJ37396
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2635 - 396 - 2002 12067236
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver,placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal 41-AA-long mitochondrial targeting peptide
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • quinone oxidoreductase subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may be involved in reticulon-induced inhibition of neurite growth
  • has a tumor-suppressive function and may regulate thyroid cancer progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with UQCRC1, UQCRC2, components of complex 3
  • with NOGO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPA10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in follicular and papillary thyroid cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS