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FLASH GENE

Symbol

RTN4IP1

contributors: mct - updated : 09-12-2015

HGNC name	reticulon 4 interacting protein 1
HGNC id	18647

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	OPA10 optic atrophy 10
Location	6q21      Physical location : 107.018.904 - 107.077.373
Genatlas name	NOGO-interacting mitochondrial protein
Synonym symbol(s)	NIMP, MGC12934

DNA

TYPE	functioning gene
STRUCTURE	59.47 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032730 9 - 2635 NP_116119 - 396 - 2002 12067236

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain

cells

System Cell Pubmed Species Stage Rna symbol Nervous astrocyte Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver,placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal 41-AA-long mitochondrial targeting peptide

HOMOLOGY

Homologene

FAMILY	zinc-containing alcohol dehydrogenase family
	quinone oxidoreductase subfamily

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	may be involved in reticulon-induced inhibition of neurite growth
	has a tumor-suppressive function and may regulate thyroid cancer progression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	with UQCRC1, UQCRC2, components of complex 3
	with NOGO

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

OPA10

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in follicular and papillary thyroid cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS