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FLASH GENE
Symbol RTN4IP1 contributors: mct - updated : 09-12-2015
HGNC name reticulon 4 interacting protein 1
HGNC id 18647
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal 41-AA-long mitochondrial targeting peptide
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc-containing alcohol dehydrogenase family
  • quinone oxidoreductase subfamily
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may be involved in reticulon-induced inhibition of neurite growth
  • has a tumor-suppressive function and may regulate thyroid cancer progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with UQCRC1, UQCRC2, components of complex 3
  • with NOGO
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) OPA10
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in follicular and papillary thyroid cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS