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FLASH GENE
Symbol RPTOR contributors: mct/pgu - updated : 13-11-2016
HGNC name regulatory associated protein of MTOR, complex 1
HGNC id 30287
Location 17q25.3      Physical location : 78.518.624 - 78.940.173
Synonym name
  • regulatory associated protein of MTOR
  • raptor
  • p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats
  • Synonym symbol(s) KOG1, Mip1, KIAA1303, raptor
    DNA
    TYPE functioning gene
    STRUCTURE 421.55 kb     34 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    34 - 6856 - 1335 - 2002 12150926
  • isoform 1
  • - - 6382 - 1177 - 2002 12150926
  • isoform 2
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     liver    
    Lymphoid/Immunelymph node   highly
    Nervousbraindiencephalonhypothalamus  
     braindiencephalonamygdala  
    Reproductivemale systemprostate   
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal RNC domain
  • three HEAT repeats
  • seven WD40 repeats at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat RAPTOR family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulates cell growth in response to nutrient and insulin levels
  • regulating through its association with FRAP1 cell size in response to nutrient level
  • positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase
  • function of RPTOR and RHEB in myogenesis is mediated by IRS1
  • distinct roles of RHEB and RPTOR in activating MTOR for the self-renewal of hematopoietic stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RHEB-MTOR/RPTOR pathway negatively regulates myogenic differentiation by suppressing IRS1-PIK3CA-AKT signaling
  • a component
  • forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase
  • complexing with FRAP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with MTOR on the outer membrane of the mitochondria is inhibited by KNK437 and triggers caspase-3 activation
  • IRS1 is a critical mediator of the myogenic functions of raptor and RHEB
  • SQSTM1 interacts in an amino acid-dependent manner with MTOR and RPTOR
  • RPTOR in MTOR complex 1 is believed to recruit EIF4EBP1, facilitating phosphorylation of EIF4EBP1 by the kinase MTOR
  • positive regulation of MTOR activity by NPRL2 is mediated through NPRL2 interaction with RPTOR
  • NPRL2 interacts with RPTOR in amino acid sufficiency to activate MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis
    Variant & Polymorphism SNP increasing the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS