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FLASH GENE
Symbol RPTOR contributors: mct/pgu - updated : 13-11-2016
HGNC name regulatory associated protein of MTOR, complex 1
HGNC id 30287
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver    
Lymphoid/Immunelymph node   highly
Nervousbraindiencephalonhypothalamus  
 braindiencephalonamygdala  
Reproductivemale systemprostate   
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal RNC domain
  • three HEAT repeats
  • seven WD40 repeats at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • WD repeat RAPTOR family
  • CATEGORY chaperone/stress , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulates cell growth in response to nutrient and insulin levels
  • regulating through its association with FRAP1 cell size in response to nutrient level
  • positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase
  • function of RPTOR and RHEB in myogenesis is mediated by IRS1
  • distinct roles of RHEB and RPTOR in activating MTOR for the self-renewal of hematopoietic stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RHEB-MTOR/RPTOR pathway negatively regulates myogenic differentiation by suppressing IRS1-PIK3CA-AKT signaling
  • a component
  • forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase
  • complexing with FRAP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with MTOR on the outer membrane of the mitochondria is inhibited by KNK437 and triggers caspase-3 activation
  • IRS1 is a critical mediator of the myogenic functions of raptor and RHEB
  • SQSTM1 interacts in an amino acid-dependent manner with MTOR and RPTOR
  • RPTOR in MTOR complex 1 is believed to recruit EIF4EBP1, facilitating phosphorylation of EIF4EBP1 by the kinase MTOR
  • positive regulation of MTOR activity by NPRL2 is mediated through NPRL2 interaction with RPTOR
  • NPRL2 interacts with RPTOR in amino acid sufficiency to activate MTOR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis
    Variant & Polymorphism SNP increasing the risk of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS