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FLASH GENE

Symbol

RPS6KA6

contributors: mct/npt - updated : 04-02-2009

HGNC name	ribosomal protein S6 kinase, 90kDa, polypeptide 6
HGNC id	10435

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xq21.1      Physical location : 83.313.353 - 83.442.943
Synonym name	ribosomal protein S6 kinase 4
	bA54F22.1.1 (ribosomal protein S6 kinase, 90kD, polypeptide 6)
	S6K-alpha 6
	p90-RSK 6
Synonym symbol(s)	RSK4, pp90RSK4
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	1156.71 kb     26 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - POU3F4 - [DXS232 - DXS8076 - DXS6946E - RPS6KA6 - DXS1519 - DXS121 ] - CHM CHM - qter
Authors	Yntema (99)
Text	see CHM

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed RPS6KA6 26 - 2637 83.74 745 - Thakur (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid         Nervous brain       highly Respiratory respiratory tract trachea       Urinary kidney         Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two non identical conserved kinase catalytic domains
	an APE motif
	a C-terminal docking site for ERK

HOMOLOGY

Homologene

FAMILY	RSK family kinases
	AGC Ser/Thr protein kinase family
	S6 kinase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleolus

basic FUNCTION	ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
	can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
	its expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule
	ATP

protein

RPS6

cell & other

REGULATION

Other

may be regulated by MYC

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast carcinoma constitutional   deletion     in complex X-linked mental retardation tumoral     --low   in colon carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS