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FLASH GENE
Symbol RPS6KA6 contributors: mct/npt - updated : 04-02-2009
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 6
HGNC id 10435
Location Xq21.1      Physical location : 83.313.353 - 83.442.943
Synonym name
  • ribosomal protein S6 kinase 4
  • bA54F22.1.1 (ribosomal protein S6 kinase, 90kD, polypeptide 6)
  • S6K-alpha 6
  • p90-RSK 6
  • Synonym symbol(s) RSK4, pp90RSK4
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 1156.71 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - POU3F4 - [DXS232 - DXS8076 - DXS6946E - RPS6KA6 - DXS1519 - DXS121 ] - CHM CHM - qter
    Authors Yntema (99)
    Text see CHM
    Physical map
    DKFZp564K142 Xq13.3 implantation-associated protein COX7B Xq13.1 cytochrome c oxidase subunit VIIb ATP7A Xq13.3 ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) PGK1 Xq13.3 phosphoglycerate kinase 1 TAF9L Xq13.1-q21.1 TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa CYSLTR1 Xq13-q21 cysteinyl leukotriene receptor 1 ZCCHC5 Xq13.3 zinc finger, CCHC domain containing 5 GPR23 Xq13-q21.1 G protein-coupled receptor 23 P2RY10 Xq21.1 purinergic receptor P2Y, G-protein coupled, 10 FKSG79 Xq13.3 putative purinergic receptor LOC347363 Xq13.3 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) ITM2A Xq13.3-q21.2 integral membrane protein 2A TBX22 Xq21.1 T-box 22 MGC26999 Xq21.1 hypothetical protein MGC26999 LOC347364 Xq21.1 similar to WW domain binding protein 11; Npw38-binding protein NpwBP; SH3 domain-binding protein SNP70 LOC286425 Xq21.1 similar to hexokinase 2; hexokinase-2, muscle FLJ38568 Xq21.1 hypothetical protein FLJ38568 LOC286426 Xq21.1 similar to Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM) NSBP1 Xq13.3 nucleosomal binding protein 1 SH3BGRL Xq13.3 SH3 domain binding glutamic acid-rich protein like LOC392500 X similar to ribosomal protein L22 LOC266683 Xq13.3 dendritic cell protein pseudogene POU3F4 Xq21.1 POU domain, class 3, transcription factor 4 LOC158668 Xq21.1 similar to Telomeric repeat binding factor 1 (TTAGGG repeat binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1) CYLC1 Xq21.1 cylicin, basic protein of sperm head cytoskeleton 1 RPS6KA6 Xq21 ribosomal protein S6 kinase, 90kDa, polypeptide 6 FLJ30678 Xq21.1 hypothetical protein FLJ30678 MGC42638 Xq21.1 hypothetical protein MGC42638 UNQ8193 Xq21.1 AAIR8193 LOC340562 Xq21.1-q21.2 hypothetical protein LOC340562 ZNF6 Xq21.1 zinc finger protein 6 (CMPX1) POF1B Xq21.2 premature ovarian failure 1B CHM Xq21.2 choroideremia (Rab escort protein 1) LOC347428 Xq21.2 similar to Stress-induced-phosphoprotein 1 (STI1) (Hsp70/Hsp90-organizing protein) (Transformation-sensitive protein IEF SSP 3521) DACH2 Xq21.3 dachshund homolog 2 (Drosophila) bA345E19.2 Xq21.31 COP9 pseudogene KLHL4 Xq21.1-q21.33 kelch-like 4 (Drosophila) LAMRL5 Xq21.31 laminin receptor-like protein LAMRL5 pseudogene MRPS22P1 Xq21.31 mitochondrial ribosomal protein S22 pseudogene 1 CAPZA1P Xq21.3 capping protein (actin filament) muscle Z-line, alpha 1 pseudogene CPXCR1 xq21-3 CPX chromosome region, candidate 1 TGIF2LX Xq21.31 TGFB-induced factor 2-like, X-linked LOC389876 X similar to staufen homolog 2; staufen (Drosophila, RNA-binding protein) 2; staufen (Drosophila, RNA-binding protein) homolog 2 USP12P2 Xq21.31 ubiquitin specific protease 12 pseudogene 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 2637 83.74 745 - Thakur (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid    
    Nervousbrain   highly
    Respiratoryrespiratory tracttrachea   
    Urinarykidney    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two non identical conserved kinase catalytic domains
  • an APE motif
  • a C-terminal docking site for ERK
  • HOMOLOGY
    Homologene
    FAMILY
  • RSK family kinases
  • AGC Ser/Thr protein kinase family
  • S6 kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
  • can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
  • its expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • RPS6
  • cell & other
    REGULATION
    Other may be regulated by MYC
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    constitutional   deletion    
    in complex X-linked mental retardation
    tumoral     --low  
    in colon carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS