Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RPS6KA6 contributors: mct/npt - updated : 04-02-2009
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 6
HGNC id 10435
DNA
TYPE functioning gene
STRUCTURE 1156.71 kb     26 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - POU3F4 - [DXS232 - DXS8076 - DXS6946E - RPS6KA6 - DXS1519 - DXS121 ] - CHM CHM - qter
Authors Yntema (99)
Text see CHM
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 2637 83.74 745 - Thakur (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid    
Nervousbrain   highly
Respiratoryrespiratory tracttrachea   
Urinarykidney    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical conserved kinase catalytic domains
  • an APE motif
  • a C-terminal docking site for ERK
  • HOMOLOGY
    Homologene
    FAMILY
  • RSK family kinases
  • AGC Ser/Thr protein kinase family
  • S6 kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, involved in neuronal development
  • can participate in non-growth factor signaling as for instance TP53-induced growth arrest (Duemmler 2005)
  • its expression may limit the oncogenic, invasive, and metastatic potential of breast cancer cells (may be, in part, due to its regulation of claudin-2) (Thakur 2008)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • RPS6
  • cell & other
    REGULATION
    Other may be regulated by MYC
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinoma
    constitutional   deletion    
    in complex X-linked mental retardation
    tumoral     --low  
    in colon carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS