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FLASH GENE
Symbol RPS27 contributors: mct - updated : 08-04-2010
HGNC name ribosomal protein S27
HGNC id 10416
Location 1q21.3      Physical location : 153.963.238 - 153.964.632
Synonym name
  • ribosomal protein S27 (metallopanstimulin 1)
  • metallopanstimulin 1
  • 40S ribosomal protein S27
  • Synonym symbol(s) MPS1, MPS-1
    DNA
    TYPE functioning gene
    STRUCTURE 1.39 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - RPL22 - RPL11 - RPS8 - RPL5 - RPS27 - qter
    Authors Uechi et al. (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 361 - 84 - Fernandez-Pol (1993)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines proliferating cells (breast cancer cell lines)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C4-type zinc finger domain
  • conjugated PhosphoP , MetalloP
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Rps27 (100.00pc)
    homolog to rattus Rps27 (100.00pc)
    Homologene
    FAMILY
  • ribosomal protein S27E family
  • CATEGORY DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • 40S ribosomal protein S27 and potentially important mediator of cellular proliferative responses to various signals (growth factors and environment)
  • playing an important role in gastric cancer cell proliferation and development (Wang 2006)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small 40S ribosomal subunit
    INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • binding one zinc Zn2+ ion per subunit
  • protein
  • may be covalently linked to translation initiation factor eIF3
  • cell & other
    REGULATION
    induced by growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in head and neck squamous cell carcinoma, reducing PXN mRNA and protein levels and thus inhibiting tumor growth (Dai 2010)
    tumoral     --over  
    mRNA level increasing in cancerous cells and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS