Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RPS27 contributors: mct - updated : 23-01-2023
HGNC name ribosomal protein S27
HGNC id 10416
Corresponding disease
DBA17 Diamond-Blackfan anemia 17
Location 1q21.3      Physical location : 153.963.238 - 153.964.632
Synonym name
  • ribosomal protein S27 (metallopanstimulin 1)
  • metallopanstimulin 1
  • 40S ribosomal protein S27
    • Synonym symbol(s) MPS1, MPS-1, DBA17, S27
    DNA
    TYPE functioning gene
    STRUCTURE 1.39 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - RPL22 - RPL11 - RPS8 - RPL5 - RPS27 - qter
    Authors Uechi et al. (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 361 - 84 - 2022 35546566
    4 - 584 - 52 - 2022 35546566
    5 - 473 - 52 - 2022 35546566
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines proliferating cells (breast cancer cell lines)
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C4-type zinc finger domain
    • conjugated PhosphoP , MetalloP
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Rps27 (100.00pc)
    homolog to rattus Rps27 (100.00pc)
    Homologene
    FAMILY
  • ribosomal protein S27E family
    • CATEGORY DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 40S ribosomal protein S27 and potentially important mediator of cellular proliferative responses to various signals (growth factors and environment)
  • playing an important role in gastric cancer cell proliferation and development (Wang 2006)
  • is involved in cell division, DNA repair, and ribosomal biogenesis, and it may be a useful antigen for studying processes such as protein synthesis, oncogenesis, regeneration, aging
  • could selectively regulate the expression of genes associated with autoimmune thyroid disease, and inflammatory/immune response
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small 40S ribosomal subunit
    INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • binding one zinc Zn2+ ion per subunit
    • protein
  • may be covalently linked to translation initiation factor eIF3
  • CDK-dependent phosphorylation of RPS27 is essential to sustain the mitotic checkpoint when few kinetochores remain unattached
  • CFTR modulates RPS27 gene expression using chloride anion as signaling effector
    • cell & other
    REGULATION
    induced by growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in head and neck squamous cell carcinoma, reducing PXN mRNA and protein levels and thus inhibiting tumor growth (Dai 2010)
    tumoral     --over  
    mRNA level increasing in cancerous cells and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS