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FLASH GENE
Symbol RPS27 contributors: mct - updated : 23-01-2023
HGNC name ribosomal protein S27
HGNC id 10416
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C4-type zinc finger domain
  • conjugated PhosphoP , MetalloP
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Rps27 (100.00pc)
    homolog to rattus Rps27 (100.00pc)
    Homologene
    FAMILY
  • ribosomal protein S27E family
  • CATEGORY DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 40S ribosomal protein S27 and potentially important mediator of cellular proliferative responses to various signals (growth factors and environment)
  • playing an important role in gastric cancer cell proliferation and development (Wang 2006)
  • is involved in cell division, DNA repair, and ribosomal biogenesis, and it may be a useful antigen for studying processes such as protein synthesis, oncogenesis, regeneration, aging
  • could selectively regulate the expression of genes associated with autoimmune thyroid disease, and inflammatory/immune response
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small 40S ribosomal subunit
    INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • binding one zinc Zn2+ ion per subunit
  • protein
  • may be covalently linked to translation initiation factor eIF3
  • CDK-dependent phosphorylation of RPS27 is essential to sustain the mitotic checkpoint when few kinetochores remain unattached
  • CFTR modulates RPS27 gene expression using chloride anion as signaling effector
  • cell & other
    REGULATION
    induced by growth factors
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in head and neck squamous cell carcinoma, reducing PXN mRNA and protein levels and thus inhibiting tumor growth (Dai 2010)
    tumoral     --over  
    mRNA level increasing in cancerous cells and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS