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FLASH GENE
Symbol RPRM contributors: mct/npt - updated : 19-03-2010
HGNC name reprimo, TP53 dependant G2 arrest mediator candidate
HGNC id 24201
Location 2q23.3      Physical location : 154.333.851 - 154.335.322
Synonym name
  • candidate mediator of the p53 dependent G2 arrest
  • REPRIMO
    • Synonym symbol(s) REPRIMO, FLJ90327
    DNA
    TYPE functioning gene
    STRUCTURE 1.47 kb     1 Exon(s)
    regulatory sequence Promoter
    text structure
  • promoter is characterized by H3K4me1/me2 (Malik 2010)
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1496 - 109 - Ohki (2000)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  moderately
    Endocrineneuroendocrinepituitary  highly
    Reproductivefemale systemovary  lowly
     male systemprostate  lowly
    Respiratorylung   highly
    Visualeye   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rprm
    Homologene
    FAMILY
  • reprimo family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducing a p53-dependent G(2) arrest of the cell cycle
  • aberrant methylation with loss of expression is a common event and may contribute to the pathogenesis of some types of malignancies
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    text cell cycle arrest
    PATHWAY
    metabolism
    signaling signal transduction
    involved in the Cdc2/cyclin B1 regulation pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with HDAC7 (Malick 2010)
    • cell & other
    REGULATION
    repressed by FOXA1 (FOXA1, well known for its role in estrogen induction of genes, is recruited to the RPRM promoter, and is necessary for repression of RPRM) (Malik 2010)
    estrogen (estrogen repression of RPRM is rapid and robust and requires a tripartite interaction between ESR1, HDAC7, and FOXA1) (Malik 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in gastric cancers, gallbladder cancers, lymphomas, colorectal cancers, esophageal adenocarcinomas, breast cancers and leukemias
    tumoral     --low  
    by hypermethylation in renal cell carcinoma (Morris 2010)
    tumoral     --other  
    aberrant methylation of RPRM is a common event in pancreatic carcinogenesis and is associated with genetic instability and unfavorable outcome after surgical resection (Sato 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene specific methylation profile associated to signet-ring cell-type histology and aberrant hypermethylation of RPRM is a potential biomarker for early detection of gastric cancer (Bernal 2008)
    Marker
    Therapy target
    ANIMAL & CELL MODELS