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FLASH GENE
Symbol RPRM contributors: mct/npt - updated : 19-03-2010
HGNC name reprimo, TP53 dependant G2 arrest mediator candidate
HGNC id 24201
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by promoter methylation in gastric cancers, gallbladder cancers, lymphomas, colorectal cancers, esophageal adenocarcinomas, breast cancers and leukemias
tumoral     --low  
by hypermethylation in renal cell carcinoma (Morris 2010)
tumoral     --other  
aberrant methylation of RPRM is a common event in pancreatic carcinogenesis and is associated with genetic instability and unfavorable outcome after surgical resection (Sato 2006)
Susceptibility
Variant & Polymorphism
Candidate gene specific methylation profile associated to signet-ring cell-type histology and aberrant hypermethylation of RPRM is a potential biomarker for early detection of gastric cancer (Bernal 2008)
Marker
Therapy target
ANIMAL & CELL MODELS