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FLASH GENE
Symbol RPL5 contributors: mct/npt - updated : 18-06-2015
HGNC name ribosomal protein L5
HGNC id 10360
Corresponding disease
DBA5 Diamond-Blackfan anemia 5
Location 1p22.1      Physical location : 93.297.593 - 93.307.480
Synonym name
  • protein phosphatase 1, regulatory subunit 135
  • 60S ribosomal protein L5
  • Synonym symbol(s) MSTP030, MGC117339, protein phosphatase 1, regulatory subunit 135
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text RNU 21 embedded in intron 5
    STRUCTURE 9.89 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D1S2865 - GBP1 - GTF2B - D1S435 - RPL5 ,D1S2776 - F3 - ABCD3 - D1S236 - D1S2775 - cen
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1035 34.2 297 - Gazda (2008)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver at the early pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N and C terminal sites of interaction with 5S RNA and of nucleolar localization signals (NLS)
  • a central nuclear export signal
  • HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein L18P family
  • CATEGORY RNA associated , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • endogenous, newly synthesized RPL5 and RPL11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with MDM2, TP53, and promyelocytic leukemia protein
  • basic FUNCTION
  • intracellular 5S RNA transport factor, nucleocytoplasmic trafficking
  • nucleocytoplasmic shuttle protein that plays an important role in 5S rRNA intracellular transport during assembly of the large ribosomal subunit
  • RPL5 and RPL11 were required for rRNA export from the nucleolus
  • unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint (pMID: 24061479)
  • RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to MYC mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of MYC activity
  • RPL5, and RPL11 can co-operatively suppress MYC expression, allowing a tightly controlled ribosome biogenesis in cells
  • RPL5 and RPL11 can enhance the transcriptional activity of a TP53 homolog TP73, but through a distinct mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts specifically with the beta subunit of casein kinase I
  • cooperates with RPL11, resulting in a robust inhibition of the E3 activity of MDM2, and a stabilization and activation of TP53 approaching that achieved by p14(ARF)
  • interaction with NPM1 mediated the colocalization of NPM1 with maturing nuclear 60S ribosomal subunits, as well as newly exported and assembled 80S ribosomes and polysomes (Yu 2006)
  • RPL11 and RPL5 activate TP73 by overcoming MDM2 inhibition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral somatic mutation      
    in 10p100 of pediatric T-cell acute lymphoblastic leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS