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FLASH GENE
Symbol RPL5 contributors: mct/npt - updated : 18-06-2017
HGNC name ribosomal protein L5
HGNC id 10360
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
 stomach   highly
Endocrineneuroendocrinepituitary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text liver at the early pregnancy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N and C terminal sites of interaction with 5S RNA and of nucleolar localization signals (NLS)
  • a central nuclear export signal
  • HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein L18P family
  • CATEGORY RNA associated , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • endogenous, newly synthesized RPL5 and RPL11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with MDM2, TP53, and promyelocytic leukemia protein
  • basic FUNCTION
  • intracellular 5S RNA transport factor, nucleocytoplasmic trafficking
  • nucleocytoplasmic shuttle protein that plays an important role in 5S rRNA intracellular transport during assembly of the large ribosomal subunit
  • RPL5 and RPL11 were required for rRNA export from the nucleolus
  • unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint (pMID: 24061479)
  • RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to MYC mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of MYC activity
  • RPL5, and RPL11 can co-operatively suppress MYC expression, allowing a tightly controlled ribosome biogenesis in cells
  • RPL5 and RPL11 can enhance the transcriptional activity of a TP53 homolog TP73, but through a distinct mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacts specifically with the beta subunit of casein kinase I
  • cooperates with RPL11, resulting in a robust inhibition of the E3 activity of MDM2, and a stabilization and activation of TP53 approaching that achieved by p14(ARF)
  • interaction with NPM1 mediated the colocalization of NPM1 with maturing nuclear 60S ribosomal subunits, as well as newly exported and assembled 80S ribosomes and polysomes (Yu 2006)
  • RPL11 and RPL5 activate TP73 by overcoming MDM2 inhibition
  • HEATR3 is a ribosome assembly factor required for mammalian 60S ribosomal subunit assembly through binding of RPL5 and RPL11
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    tumoral somatic mutation      
    in 10p100 of pediatric T-cell acute lymphoblastic leukemias
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS