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FLASH GENE
Symbol RNF43 contributors: mct/pgu - updated : 23-12-2015
HGNC name ring finger protein 43
HGNC id 18505
Location 17q22      Physical location : 56.431.039 - 56.494.931
Synonym symbol(s) RNF124, FLJ20315, DKFZp781H0392, URCC, DKFZp781H02126, FLJ77466, FLJ99338, MGC125630
DNA
TYPE functioning gene
STRUCTURE 63.94 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4573 - 783 - 2008 18313049
- - 5543 - 783 - -
- - 4625 - 656 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveenterocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text low levels of expression in fetal kidney and lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • RING zinc finger motif
  • two C-terminal nuclear localization
  • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to ZNRF3
    Homologene
    FAMILY
  • RING zinc finger ptoein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text
  • resident protein of the ER and, at least partially, the nuclear membrane
  • basic FUNCTION
  • acts as a ubiquitin ligase with autoubiquitylating activity
  • oncogenic RING finger protein
  • promotes cell growth
  • likely plays a crucial role for regulating wild-type TP53-associated apoptotic cell death
  • RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation
  • molecular role of RNF43 in canonical and noncanonical Wnt signaling
  • plays important roles in tumor formation progression, and might act as a tumor suppressor in gastric carcinoma
  • E3 ubiquitin ligase originally found in stem cells, and inhibiting the Wnt pathway downstream of oncogenic mutations that activate the pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • AKAP8L, a chromatin-associated protein interfacing the nuclear envelope, is an RNF43-interacting protein
  • SFPQ is a binding partner
  • binds to NEDD-4-like ubiquitin-protein ligase-1 (HECW1), which enhances pro-apoptotic activity by TP53
  • associated with TP53-mediated apoptosis in collaboration with HECW1 in colorectal carcinogenesis
  • RNF43 binds to NEDD-4-like ubiquitin-protein ligase-1 (HECW1), which enhances pro-apoptotic activity by TP53
  • membrane-located tumourigenesis inhibitors RNF43 and ZNRF3 mediating the degradation of the Wnt receptor components FZDS and LRP5/6
  • LGR5 does not contact RNF43 but increases the affinity of RSPO1 to RNF43, supporting LGR5 as an engagement receptor and RNF43 as an effector receptor
  • DVL1 is a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity
  • ZNRF3/RNF43--a direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling
  • RNF43 physically interacted with T cell factor 4 (TCF4) in cells and tethered TCF4 to the nuclear membrane, thus silencing TCF4 transcriptional activity even in the presence of constitutively active mutants of CTNNB1
  • DDB2 is critical for CTNNB1-mediated activation of RNF43, which restricts WNT signaling by removing WNT receptors from the cell surface
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer (
    tumoral somatic mutation      
    frequent in gastric cancer5)
    tumoral     --low  
    increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a novel diagnostic marker for colorectal cancer
  • might be a potential indicator for the clinical assessment of gastric cancer prognosis
  • Therapy target
    ANIMAL & CELL MODELS