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FLASH GENE
Symbol RNF43 contributors: mct/pgu - updated : 20-04-2022
HGNC name ring finger protein 43
HGNC id 18505
ASSOCIATED DISORDERS
corresponding disease(s) SSPCS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal cancer (
tumoral somatic mutation      
frequent in gastric cancer5)
tumoral     --low  
increases membrane expression of frizzled receptor in pancreatic ductal adenocarcinoma
tumoral     --low  
in clear cell renal cell carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • may be a novel diagnostic marker for colorectal cancer
  • might be a potential indicator for the clinical assessment of gastric cancer prognosis
  • presence of RNF43 mutations could be used as a predictive biomarker for patient selection supporting the clinical development of Wnt inhibitors in subtypes of cancer
  • RNF43 is a possible biomarker for therapy selection in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    harnessing phospho-regulation of RNF43 might be a potential therapeutic strategy for tumours with RNF43 mutations
    ANIMAL & CELL MODELS