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FLASH GENE
Symbol RNF216 contributors: mct/npt - updated : 16-03-2010
HGNC name ring finger protein 216
HGNC id 21698
Location 7p22.1      Physical location : 5.659.677 - 5.821.292
Synonym name
  • ubiquitin conjugating enzyme 7 interacting protein 1
  • zinc finger protein inhibiting NF- kappa-B
  • triad domain-containing protein 3
  • Synonym symbol(s) TRIAD3, U7I1, UBCE7IP1, ZIN
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 161.61 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 5793 - 923 - Fearns (2006)
    17 - 5622 99 866 - Fearns (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a double ring finger linked (DRIL) motif
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • E3 ubiquitin-protein ligase that interacts with the Toll/interleukin-1 receptor domain of TLRs and promotes their proteolytic degradation (Fearns 2006)
  • versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection (Nakhaei 2009)
  • appear to be involved in the movement of TLR4 to the lysosome for degradation (McGettrick 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • E3 ubiquitin-protein ligase to RIPK1 and Hsp90 and RNF216 cooperatively maintain the homeostasis of RIPK1 (Fearns 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS