| 1 | RNF216, TLR8
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| Toll-Like Receptor 8 Stability is Regulated by Ring Finger 216 in response to circulating MicroRNAs.
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| Evankovich J, Lear T, Baldwin C, Chen Y, White V, Villandre J, Londino J, Liu Y, McVerry B, Kitsios GD, Mallampalli RK, Chen BB.
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| Am J Respir Cell Mol Biol m J Respir Cell Mol Biol. 2019 Aug 6. doi: 10.1165/rcmb.2018-0373OC. [Epub ahead of print]
2019
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| 2 | GDHS, RNF216
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| Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.
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| Seenivasan R, Hermanns T, Blyszcz T, Lammers M, Praefcke GJK, Hofmann K.
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| Hum Mol Genet 28(17):2862-2873. doi: 10.1093/hmg/ddz098.
2019
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| 3 | GDHS, RNF216
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| TRIAD3/RNF216 E3 ligase specifically synthesises K63-linked ubiquitin chains and is inactivated by mutations associated with Gordon Holmes syndrome.
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| Schwintzer L, Aguado Roca E, Broemer M.
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| Cell Death Discov 5:75. doi: 10.1038/s41420-019-0158-6. eCollection 2019.
2019
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| 4 | BECN1, GNRH1, RNF216
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| RNF216 Regulates the Migration of Immortalized GnRH Neurons by Suppressing Beclin1-Mediated Autophagy.
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| Li F, Li D, Liu H, Cao BB, Jiang F, Chen DN, Li JD.
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| Front Endocrinol (Lausanne) 10:12. doi: 10.3389/fendo.2019.00012. eCollection 2019.
2019
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| 5 | RNF216
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| RNF216 is essential for spermatogenesis and male fertility†.
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| Melnick AF, Gao Y, Liu J, Ding D, Predom A, Kelly C, Hess RA, Chen C.
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| Biol Reprod 100(5):1132-1134. doi: 10.1093/biolre/ioz006.
2019
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| 6 | GDHS, RNF216
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| TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.
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| Husain N, Yuan Q, Yen YC, Pletnikova O, Sally DQ, Worley P, Bichler Z, Shawn Je H.
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| Aging Cell 16(2):281-292. doi: 10.1111/acel.12551. Epub 2016 Dec 20.
2017
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| 7 | RNF216
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| RNF216 contributes to proliferation and migration of colorectal cancer via suppressing BECN1-dependent autophagy.
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| Wang H, Wang Y, Qian L, Wang X, Gu H, Dong X, Huang S, Jin M, Ge H, Xu C, Zhang Y.
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| Oncotarget 7(32):51174-51183. doi: 10.18632/oncotarget.9433.
2016
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| 8 | GDHS, RNF216
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| RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.
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| Santens P, Van Damme T, Steyaert W, Willaert A, Sablonnière B, De Paepe A, Coucke PJ, Dermaut B.
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| Neurology 84(17):1760-6. doi: 10.1212/WNL.0000000000001521. Epub 2015 Apr 3.
2015
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| 9 | BECN1, RNF216
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| Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.
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| Xu C, Feng K, Zhao X, Huang S, Cheng Y, Qian L, Wang Y, Sun H, Jin M, Chuang TH, Zhang Y.
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| Autophagy 10(12):2239-50. doi: 10.4161/15548627.2014.981792.
2014
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| 10 | GDHS, RNF216
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| Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.
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| Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB.
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| N Engl J Med 368(21):1992-2003. doi: 10.1056/NEJMoa1215993. Epub 2013 May 8.
2013
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| 11 | KIR2DL4, RNF216
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| Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-κB signaling.
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| Miah SM, Purdy AK, Rodin NB, MacFarlane AW 4th, Oshinsky J, Alvarez-Arias DA, Campbell KS.
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| J Immunol 186(5):2959-69. doi: 10.4049/jimmunol.1000112. Epub 2011 Jan 26.
2011
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| 12 | CNPY3, HSP90B1, RNF216, UNC93B1
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| Localisation and trafficking of Toll-like receptors: an important mode of regulation.
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| McGettrick AF, O'Neill LA.
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| Curr Opin Immunol 22(1):20-7. Epub 2010 Jan 7.PMID: 20060278 2010
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| 13 | RNF216
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| The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
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| Nakhaei P, Mesplede T, Solis M, Sun Q, Zhao T, Yang L, Chuang TH, Ware CF, Lin R, Hiscott J.
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| PLoS Pathog 5(11):e1000650. Epub 2009 Nov 6.PMID: 19893624 2009
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| 14 | RIPK1, RNF216
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| Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding.
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| Fearns C, Pan Q, Mathison JC, Chuang TH.
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| J Biol Chem 281(45):34592-600. Epub 2006 Sep 12.PMID: 16968706 2006
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| 15 | RNF216
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| Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.
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| Chuang TH, Ulevitch RJ.
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| Nat Immunol 5(5):495-502. Epub 2004 Apr 25. Erratum in: Nat Immunol. 2004 Sep;5(9):968. PMID: 15107846 2004
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| 16 | ARIH2, RNF216, RNF31
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| TRIADs: a new class of proteins with a novel cysteine-rich signature.
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| van der Reijden BA, Erpelinck-Verschueren CA, Lowenberg B, Jansen JH.
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| Protein Sci 8(7):1557-61. 1999
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