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FLASH GENE
Symbol RNF123 contributors: mct/npt - updated : 28-04-2009
HGNC name ring finger protein 123
HGNC id 21148
Location 3p21.31      Physical location : 49.726.989 - 49.758.961
Synonym name
  • Kip1 ubiquitylation-promoting complex
  • ubiquitin ligase
    • Synonym symbol(s) FLJ12565, DKFZp686C2222, FP1477, KPC1, MGC163504
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 31.97 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 - 4272 148.4 1314 - Kotoshiba (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH(2)-terminal region responsible for binding to CDKN1C and to CDKN1B
  • a RING finger
  • a SPRY domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text like USP19, is localized to the cytosol (Lu 2009)
    basic FUNCTION
  • regulates the ubiquitin-dependent degradation of CDKN1B at G(1) phase (Kotoshiba 2005)
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
    • protein
  • interacts with USP19 (stabilizes RNF123, by deubiquitinating it and protecting it from ubiquitin-proteasome-dependent degradation) (Lu 2009)
  • USP19 positively regulates proliferation in fibroblasts by stabilizing RNF123, a ubiquitin ligase for CDKN1B
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS