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FLASH GENE
Symbol RNF123 contributors: mct/npt - updated : 28-04-2009
HGNC name ring finger protein 123
HGNC id 21148
Location 3p21.31      Physical location : 49.726.989 - 49.758.961
Synonym name
  • Kip1 ubiquitylation-promoting complex
  • ubiquitin ligase
  • Synonym symbol(s) FLJ12565, DKFZp686C2222, FP1477, KPC1, MGC163504
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 31.97 kb     39 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene) GPX1 3p21.2 glutathione peroxidase 1 ARHA 3p21.2 ras homolog gene family, member A TCTA 3p21 T-cell leukemia translocation altered gene AMT 3p21.2 aminomethyltransferase (glycine cleavage system protein T) NICN1 3p21.31 nicolin 1 DAG1 3p21.2-p21.1 dystroglycan 1 (dystrophin-associated glycoprotein 1) BSN 3p21.31 bassoon (presynaptic cytomatrix protein) APEH 3p21.3-p21.2 N-acylaminoacyl-peptide hydrolase MST1 3p21.31 macrophage stimulating 1 (hepatocyte growth factor-like) RNF123 3p24.3 ring finger protein 123 GMPPB 3p21.31 GDP-mannose pyrophosphorylase B IHPK1 3p21.31 inositol hexaphosphate kinase 1 LOC389117 3 similar to mouse fat 1 cadherin LOC389118 3 similar to VLLR9392 LOC389119 3 similar to RIKEN cDNA 6530418L21 UBE1L 3p21.2 ubiquitin-activating enzyme E1-like TRIP 3p21.31 TRAF interacting protein MGC8407 3p21.31 hypothetical protein MGC8407 LOC389120 3 similar to RIKEN cDNA 4921517D21 LOC285405 3p21.31 similar to RIKEN cDNA 4921517D21 MST1R 3p21.3 macrophage stimulating 1 receptor (c-met-related tyrosine kinase) MGC13272 3p21.31 hypothetical protein MGC13272 RBM6 3p21.3 RNA binding motif protein 6 RBM5 3p21.3 RNA binding motif protein 5 SEMA3F 3p21.31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F GNAT1 3p21.2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    39 - 4272 148.4 1314 - Kotoshiba (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH(2)-terminal region responsible for binding to CDKN1C and to CDKN1B
  • a RING finger
  • a SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text like USP19, is localized to the cytosol (Lu 2009)
    basic FUNCTION
  • regulates the ubiquitin-dependent degradation of CDKN1B at G(1) phase (Kotoshiba 2005)
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacts with USP19 (stabilizes RNF123, by deubiquitinating it and protecting it from ubiquitin-proteasome-dependent degradation) (Lu 2009)
  • USP19 positively regulates proliferation in fibroblasts by stabilizing RNF123, a ubiquitin ligase for CDKN1B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS