Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF123 contributors: mct/npt - updated : 28-04-2009
HGNC name ring finger protein 123
HGNC id 21148
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
39 - 4272 148.4 1314 - Kotoshiba (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NH(2)-terminal region responsible for binding to CDKN1C and to CDKN1B
  • a RING finger
  • a SPRY domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text like USP19, is localized to the cytosol (Lu 2009)
    basic FUNCTION
  • regulates the ubiquitin-dependent degradation of CDKN1B at G(1) phase (Kotoshiba 2005)
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • interacts with USP19 (stabilizes RNF123, by deubiquitinating it and protecting it from ubiquitin-proteasome-dependent degradation) (Lu 2009)
  • USP19 positively regulates proliferation in fibroblasts by stabilizing RNF123, a ubiquitin ligase for CDKN1B
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS