1 | RLN2, S100A4
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| Prognostic significance of relaxin-2 and S100A4 expression in osteosarcoma.
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| Huang H, Zheng HY, Liu ZL, Zhang L.
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| Eur Rev Med Pharmacol Sci 18(19):2828-34.
2014
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2 | RLN2, RLN3, RXFP1, RXFP2
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| The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
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| Kong RC, Petrie EJ, Mohanty B, Ling J, Lee JC, Gooley PR, Bathgate RA.
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| J Biol Chem 288(39):28138-51. doi: 10.1074/jbc.M113.499640. Epub 2013 Aug 7.
2013
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3 | RLN2, RLN3
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| The plasma levels of relaxin-2 and relaxin-3 in patients with diabetes.
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| Zhang X, Zhu M, Zhao M, Chen W, Fu Y, Liu Y, Liu W, Zhang B, Yin X, Bai B.
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| Clin Biochem 46(16-17):1713-6. doi: 10.1016/j.clinbiochem.2013.08.007. Epub 2013 Aug 28.
2013
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4 | RLN2
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| Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial.
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| Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Ponikowski P, Unemori E, Voors AA, Adams KF Jr, Dorobantu MI, Grinfeld LR, Jondeau G, Marmor A, Masip J, Pang PS, Werdan K, Teichman SL, Trapani A, Bush CA, Saini R, Schumacher C, Severin TM, Metra M; RELAXin in Acute Heart Failure (RELAX-AHF) Investigators.
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| Lancet 381(9860):29-39. doi: 10.1016/S0140-6736(12)61855-8. Epub 2012 Nov 7.
2013
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5 | RLN2
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| Genetic associations of relaxin: preterm birth and premature rupture of fetal membranes.
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| Rocha FG, Slavin TP, Li D, Tiirikainen MI, Bryant-Greenwood GD.
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| Am J Obstet Gynecol 209(3):258.e1-8. doi: 10.1016/j.ajog.2013.05.020. Epub 2013 May 10.
2013
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6 | RLN2
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| Human relaxin-2: historical perspectives and role in cancer biology.
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| Nair VB, Samuel CS, Separovic F, Hossain MA, Wade JD.
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| Amino Acids 43(3):1131-40. doi: 10.1007/s00726-012-1375-y. Epub 2012 Aug 2. Review.
2012
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7 | RLN2
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| Relaxin-2 may offer therapeutic advantages in end-stage heart failure.
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| Zhao Z, Liu T, Li G.
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| Int J Cardiol 157(3):432-3. doi: 10.1016/j.ijcard.2012.03.169. Epub 2012 Apr 27. No abstract available.
2012
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8 | RLN2, RXFP1, RXFP2
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| Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.
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| Hampel U, Klonisch T, Makrantonaki E, Sel S, Schulze U, Garreis F, Seltmann H, Zouboulis CC, Paulsen FP.
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| Invest Ophthalmol Vis Sci 53(12):7780-90. doi: 10.1167/iovs.12-10714. Erratum in: Invest Ophthalmol Vis Sci. 2014;55(6):3998. Makrantonaki, Eugenia [added 2012
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9 | RLN2
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| Relaxin 2 is functional at the ocular surface and promotes corneal wound healing.
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| Hampel U, Klonisch T, Makrantonaki E, Sel S, Schulze U, Garreis F, Seltmann H, Zouboulis CC, Paulsen FP.
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| Invest Ophthalmol Vis Sci 53(12):7780-90. doi: 10.1167/iovs.12-10714. Erratum in: Invest Ophthalmol Vis Sci. 2014;55(6):3998. Makrantonaki, Eugenia [added 2012
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10 | RLN2
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| The minimal active structure of human relaxin-2.
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| Hossain MA, Rosengren KJ, Samuel CS, Shabanpoor F, Chan LJ, Bathgate RA, Wade JD.
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| J Biol Chem 286(43):37555-65. doi: 10.1074/jbc.M111.282194. Epub 2011 Aug 30.
2011
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11 | RLN2
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| Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth.
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| Vogel I, Hollegaard MV, Hougaard DM, Thorsen P, Grove J.
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| In Vivo 23(6):1005-9.
2009
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12 | RLN2
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| Effects of recombinant H2 relaxin on the expression of matrix metalloproteinases and tissue inhibitor metalloproteinase in cultured early placental extravillous trophoblasts.
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| Maruo N, Nakabayashi K, Wakahashi S, Yata A, Maruo T.
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| Endocrine 32(3):303-10. doi: 10.1007/s12020-008-9034-5. Epub 2008 Jan 31.
2007
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13 | RLN2
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| H2 relaxin overexpression increases in vivo prostate xenograft tumor growth and angiogenesis.
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| Silvertown JD, Ng J, Sato T, Summerlee AJ, Medin JA.
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| Int J Cancer 118(1):62-73. 2006
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14 | RLN1, RLN2, RLN3
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| Regulation of the human relaxin genes H1 and H2 by steroid hormones.
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| Garibay-Tupas JL, Okazaki KJ, Tashima LS, Yamamoto S, Bryant-Greenwood GD.
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| Mol Cell Endocrinol 219(1-2):115-25. 2004
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15 | RLN1, RLN2, RXFP1
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| Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle.
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| Bond CP, Parry LJ, Samuel CS, Gehring HM, Lederman FL, Rogers PA, Summers RJ.
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| J Clin Endocrinol Metab 89(7):3477-85. 2004
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16 | RLN1, RLN2
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| Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes.
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| Garibay-Tupas JL, Bao S, Kim MT, Tashima LS, Bryant-Greenwood GD.
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| J Mol Endocrinol 24(2):241-52. 2000
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17 | RLN2
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| Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping.
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| Garibay-Tupas JL, Csiszar K, Fox M, Povey S, Bryant-Greenwood GD.
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| J Mol Endocrinol 23(3):355-65. 1999
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18 | RLN1, RLN2
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| Two human relaxin genes are on chromosome 9.
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| Crawford RJ, et al.
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| EMBO J 3 : 2341-2345. 1984
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