| basic FUNCTION
| dual-function molecule that can be either prosurvival or prodeath depending on its ubiquitination state, and this serves as an NF-kappaB-independent cell-death switch early in TNF signaling |
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playing an important role for DNA damage-induced, TP53-independent cell death |
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one of the critical components involved in mediating DNA damage-induced, TP53-independent cell death |
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one of the major components of the tumor necrosis factor receptor 1 complex and plays an essential role in tumor necrosis factor-mediated nuclear factor kappaB activation ( |
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plays a critical role in tumor necrosis factor-alpha (TNF)-induced IkappaB kinase (IKK) activation and subsequent activation of transcription factor NF-kappaB |
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inhibiting the expression of the epidermal growth factor receptor (EGFR) |
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crucial modulator of epidermal differentiation, and important and unique functions in keratinocytes of normal and wounded skin |
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critical mediator of inflammation and stress-induced NF-kappaB activation, regulates the expression of the epidermal growth factor receptor (EGFR) |
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downregulates EGFR expression by interfering with the function of Sp1, which is a key activator of EGFR transcription |
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specifically recruited to the TNFalpha receptor in the activation of necroptosis |
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required for death receptor agonists to activate necrosis |
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RIPK1 and RIPK3 are key signaling molecules in necrosis and are regulated by caspases and ubiquitination |
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required for CD40 ligand-induced caspase-8 activation and tumor cell killing |
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RIPK1 and caspase-8 were recruited to the DDX58 complex after viral infection and served antagonistic regulatory roles |
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regulates embryogenesis and lymphocyte responses ( |
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a IKBKG- and RIPK1-based switch mechanism involving TNF-TNFR1 feedforward signaling that mediates ATM-induced cytokine secretion and caspase activation selectively in the context of severe DNA damage |
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is a central kinase in TNFR1 signaling participating in NFKB activation, necroptosis, and apoptosis |
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functions as a platform mediating survival signals and as an active kinase during necroptosis and apoptosis in the presence of Smac mimetics |
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RIPK1, RIPK3 are central players in TNF-induced programmed necrosis |
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key switch of cell fate regulation |
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necroptosis is controlled by the action of two serine/threonine kinases, RIPK1 and RIPK3 |
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RIPK1 can activate RIPK3 in response to receptor signaling, but also acts as a negative regulator of spontaneous RIPK3 activation in the cytosol |
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is essential for survival of intestinal epithelial cells (IECs), ensuring epithelial homeostasis by protecting the epithelium from CASP8-mediated IEC apoptosis independently of its kinase activity and NFKB1 activation |
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RIPK1 is dispensable for necroptosis and can act as an inhibitor of this process |
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key player in inflammation and cell death, that assumes opposite functions depending on the cellular context and its posttranslational modifications |
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is essential for the regulation of death receptor mediated autophagy and apoptosis |
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RIPK1 and RIPK3 directly regulate inflammatory signaling, which complicates interpretation of their function but might alter their therapeutic utility |
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RIPK1 and RIPK3 play a critical role in mediating progressive axonal degeneration |
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RIPK1 regulates cell death and inflammation through kinase-dependent and -independent functions |
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inhibits apoptosis and necroptosis through kinase-independent functions, which are important for late embryonic development and the prevention of inflammation in epithelial barriers |
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enzyme acting downstream of tumor necrosis factor alpha to control cell survival and death |
