protein
| Fas/APO-1 (CD95) ( |
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TNFRSF1A-associated via death domain, TRADD ( |
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FADD/MORT1 ( |
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Death receptor 4, DR4 and Death receptor 5, DR5 ( |
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TNFRSF1A |
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aPKC-binding protein, p62 ( |
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heat shock protein 90, Hsp90 ( |
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NEMO (IKKgamma) ( |
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epidermal growth factor receptor, EGFR ( |
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IKBKG and modulatory NF6kappa B activation and apoptosis |
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RIPK3 |
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zinc finger protein inhibiting NF-kappa B ( |
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Focal adhesion kinase, FAK ( |
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RNF216 (E3 ubiquitin-protein ligase to RIPK1 and Hsp90 and RNF216 cooperatively maintain the homeostasis of RIPK1 |
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cylindromatosis (turban tumor syndrome), CYLD ( |
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CSNK1A1 |
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TAK1 kinase ( |
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ZBP1 recruits RIPK1 and RIPK3 through RIP homotypic interaction motifs to activate NF-kappaB |
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ubiquitin specific peptidase 21, USP21 |
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links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas |
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RIPK1 |
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CD40 ( |
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interacting with ATM (in the context of excessive DNA damage, ATM employs IKBKG and RIPK1 through autocrine TNF signaling to switch on cytokine production and caspase activation) |
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FCMR regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIPK1 ubiquitination |
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PGAM5 is a kinase substrate of RIPK1/RIPK3 |
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necroptosis depends on the kinases RIPK1 and RIPK3, which interact through their RHIM domains to form the necrosome |
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recruitment of IKBKG to ubiquitinated RIPK1 is a key step in the TNFR1 signaling pathway that determines whether RIPK1 triggers a necrotic death response |
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RIPK1 is a critical target of SIRT2-dependent deacetylation |
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AKT1 activity, mediated in part through MTOR, links RIPK1 to JNK activation and autocrine production of TNF |
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likely TNF-induced necroptosis is tightly associated with oxidative stress, and oxidative stress is induced downstream of RIPK1 activation |
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PELI3 targets RIPK1, in a TNF-dependent manner, to inhibit TNF-induced complex II formation |
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TRADD is an adapter molecule that bridges the interaction between TNFRSF1A and receptor-interacting serine/threonine-protein kinase 1 (RIPK1) |
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intrinsically suppresses spontaneous RIPK3 activation in the cytosol by controlling RIPK3 oligomerization |
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regulates hematopoiesis and prevents inflammation by suppressing RIPK3 activation |
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indirectly regulates likely CASP8 activation, in part via interaction with the ER stress sensor inositol-requiring protein 1 (ERN1) |
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ZFP36 promotes the assembly of the death complex called Ripoptosome and induces RIPK1-dependent death |
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EGLN3 is a novel binding protein of RIPK1 (C-terminal region of EGLN3 is responsible for its interaction with RIPK1) |
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EGLN3 interferes with the association between RIPK1 and BIRC2, and attenuates RIPK1-induced NFKB1 activation |
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RHIM motif of RIPK1 is critical for preventing ZBP1/RIPK3/MLKL-dependent necroptosis during development |
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unexpected roles for RIPK1 and RIPK3 kinases in the production of IFNB1 during the host inflammatory responses to bacterial infection, suggesting that the axis in which these kinases operate may represent a target for bacterial virulence factors |
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ubiquitination of RIPK1 by PELI1 promotes the formation of necrosome and execution of necroptosis |
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functions as a key mediator of tissue homeostasis via formation of CASP8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation |
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PLK1 is recruited into mitotic ripoptosomes, where PLK1's activity is controlled via RIPK1-dependent recruitment and CASP8-mediated cleavage |
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TRADD plays a more dominating role in NFKB1-signaling than RIPK1 |
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HTRA2 directly interacted with RIPK1 and promoted its degradation during a specific time phase of necroptosis |